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B 581
blocks farnesylated but not geranylgeranylated or myristylated, oncogenic Ras signaling & transformation
Also Known As:
B-581; B581
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Oligopeptides: 519
B 581: 1
Experts
1.
Jorquera, R
: 1 article (08/2001)
2.
Tanguay, R M
: 1 article (08/2001)
Related Diseases
1.
Chromosomal Instability (Chromosome Stability)
08/15/2001 - "
Pre-treatment with the MEK inhibitor PD98059 and the Ras farnesylation inhibitor B581 decreased the formation of CREST-positive micronuclei by approximately 75%, confirming the partial contribution of the Ras/ERK effector pathway to the induction of chromosomal instability by FAA.
"
Related Drugs and Biologics
1.
Mitogen-Activated Protein Kinase Kinases (MEKs)
2.
2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- one