SR 31747

a sigma receptor antagonist and steroid isomerase inhibitor with immunosuppressive and anti-inflammatory activities; structure given in first source

Also Known As:

N-cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexylphenyl)propen-2-ylamine hydrochloride; SR 31747A; SR-31747; SR31747; Cyclohexanamine, N-((2Z)-3-(3-chloro-4-cyclohexylphenyl)-2-propen-1-yl)-N-ethyl-, hydrochloride (1:1)

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        SR 31747: 3

Related Diseases

1.	Graft vs Host Disease (Graft-Versus-Host Disease) 07/01/1994 - "In vivo, in mice, treatment with SR 31747 prevented both graft-versus-host disease and delayed-type hypersensitivity granuloma formation, while antibody response to sheep red blood cells was not affected. " 09/01/1995 - "The sigma ligand SR 31747 prevents the development of acute graft-versus-host disease in mice by blocking IFN-gamma and GM-CSF mRNA expression."
2.	Hypersensitivity (Allergy) 07/01/1994 - "In vivo, in mice, treatment with SR 31747 prevented both graft-versus-host disease and delayed-type hypersensitivity granuloma formation, while antibody response to sheep red blood cells was not affected. "
3.	Granuloma 07/01/1994 - "In vivo, in mice, treatment with SR 31747 prevented both graft-versus-host disease and delayed-type hypersensitivity granuloma formation, while antibody response to sheep red blood cells was not affected. "
4.	Autoimmune Diseases (Autoimmune Disease) 01/01/1995 - "The combination of immunosuppression, previously described, along with anti-inflammatory properties makes SR 31747 a novel attractive molecule for therapeutic applications such as autoimmune diseases in which both immune and inflammatory disorders are involved."

Related Drugs and Biologics

1.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
2.	Messenger RNA (mRNA)
3.	Ligands