|1.||Chen, Li-Mei: 11 articles (01/2015 - 01/2002)|
|2.||Chai, Karl X: 11 articles (01/2015 - 01/2002)|
|3.||Caughey, George H: 6 articles (01/2015 - 01/2003)|
|4.||Chao, Julie: 6 articles (08/2013 - 02/2002)|
|5.||Chen, Mengqian: 5 articles (05/2008 - 06/2006)|
|6.||Bugge, Thomas H: 4 articles (05/2014 - 10/2007)|
|7.||Jensen, Boye L: 3 articles (05/2015 - 01/2015)|
|8.||Svenningsen, Per: 3 articles (05/2015 - 01/2015)|
|9.||Zhang, J: 3 articles (01/2015 - 01/2014)|
|10.||Friis, Stine: 3 articles (05/2014 - 01/2009)|
|1.||Hyperaldosteronism (Conn Syndrome)
09/01/2012 - "Urinary exosomal pNCC and, to a lesser extent, prostasin are promising markers for aldosteronism in experimental animals and patients. "
10/01/2005 - "In contrast, prostasin paradoxically increased in urine of patients affected by primary aldosteronism after volume expansion. "
02/01/2002 - "In patients with primary aldosteronism, reduction in the urinary excretion of prostasin correlated with the increase in the urinary Na/K ratio. "
02/01/2002 - "Finally, urinary excretion of prostasin in patients with primary aldosteronism was substantially increased when compared with normal patients. "
09/01/2012 - "In urinary exosomes of patients with primary aldosteronism, pNCC was 2.6-fold higher (P<0.05) while prostasin was 1.5-fold higher (P=0.07) than in patients with essential hypertension. "
01/01/2014 - "In vivo studies indicate that forced overexpression of prostasin in drug-resistant cells greatly inhibits the growth of tumors and may partially reverse drug resistance. "
10/01/2013 - "In this study, the protein levels of Axl and prostasin in malignant neoplasms of the ovary and their clinicopathologic significance were investigated. "
01/01/2014 - "Our cell cultural model investigation demonstrates prostasin has important roles in the development of drug resistance and cancer cell survival. "
01/01/2009 - "Immunohistochemical analysis of prostasin and HAI-1 was performed on normal and cancer tissue. "
12/01/2008 - "Prostasin is considered to have suppressive activities against tumor progression. "
|3.||Ovarian Neoplasms (Ovarian Cancer)
01/01/2014 - "In this study, we show that prostasin is decreased in an ovarian cancer drug-resistant cell line and in ovarian cancer patients with high levels of excision repair cross-complementing 1, a marker for chemoresistance. "
01/01/2009 - "This study sought to evaluate the expression of prostasin in ovarian cancer. "
01/01/2009 - "A previous study showed that prostasin is highly overexpressed in ovarian cancer cell lines. "
01/01/2014 - "Thus, PSP94/prostasin axis appears to be linked to the Lin28b/Let-7 loop, a well-known signaling mechanism in oncogenesis in general that is also altered in ovarian cancer. "
01/01/2014 - "Expression of PSP94 and prostasin show a strong correlation with the expression levels of Lin28b/Let-7 in ovarian cancer patients. "
|4.||Prostatic Neoplasms (Prostate Cancer)
01/01/2001 - "The aim of this study was to establish the specific detection of prostasin-expressing prostate cells in the blood of patients with prostate cancer. "
12/01/2009 - "The PC-3 human prostate cancer cell line was used for evaluation of gene expression in response to prostasin re-expression. "
04/01/2004 - "The invasion suppressor prostasin is down-regulated in prostate cancer, but the mechanism is unknown. "
07/01/2001 - "Our data indicate that prostasin may be implicated in normal prostate biology and is able to suppress prostate cancer invasion in vitro."
07/01/2001 - "Immunohistochemistry analysis showed that prostasin protein expression is down-regulated in high-grade prostate cancer. "
|5.||Cystic Fibrosis (Mucoviscidosis)
11/01/2004 - "This study tests the hypothesis that prostasin can regulate ENaC in cystic fibrosis epithelia in which excessive Na+ uptake contributes to salt and water imbalance. "
05/01/2008 - "Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis."
11/01/2004 - "These data predict that prostasin is a major regulator of ENaC-mediated Na+ current in DeltaF508 cystic fibrosis epithelia and suggest that airway prostasin is a target for therapeutic inhibition to normalize ion current in cystic fibrosis airway."
11/01/2004 - "We show that prostasin mRNA and protein are strongly expressed by human airway epithelial cell lines, including immortalized JME/CF15 nasal epithelial cells homozygous for the DeltaF508 cystic fibrosis mutation. "
01/01/2013 - "Understanding the mechanism by which prostasin and its inhibitors regulate sodium channels has provided a new insight into the treatment of hypertension and some other diseases like cystic fibrosis. "
|1.||Sodium Chloride Symporters
|2.||Serine Proteases (Serine Protease)
|3.||Messenger RNA (mRNA)
|5.||Staphylococcal Protein A (A, Protein)
|6.||Protease Inhibitors (Protease Inhibitor)
|8.||Biological Markers (Surrogate Marker)
|9.||Epithelial Sodium Channel
|1.||Drug Therapy (Chemotherapy)