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MDL 101146
orally active inhibitor of neutrophil elastase; structure in first source
Also Known As:
MDL 101,146; MDL-101,146; MDL-101146; N-(4-(4-morpholinylcarbonyl)benzoyl)valyl-N-(3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl)prolinamide
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Halogenated Hydrocarbons: 42
Fluorinated Hydrocarbons: 4
Fluorocarbons: 1209
MDL 101146: 3
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Oxazines: 9
Morpholines: 6
MDL 101146: 3
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Oligopeptides: 519
MDL 101146: 3
Related Diseases
1.
Lung Injury
08/01/1994 - "
These results suggest that sulfated polymers such as MDL 101,146 may be useful as inhibitors of HNE-mediated lung injury.
"
2.
Hemorrhage
07/01/1994 - "
MDL 101,146 had no effect on thermolysin-induced pulmonary hemorrhage, which demonstrated the specificity of MDL 101,146 for HNE in vivo.
"
07/01/1994 - "
Oral administration of MDL 101,146 to hamsters at 10, 25 and 50 mg/kg before an intratracheal instillation of HNE inhibited pulmonary hemorrhage with an ED50 of 15 mg/kg. The duration of action of MDL 101,146 (50 mg/kg p.o.) for the inhibition of HNE-induced hemorrhage was between 2 and 4 hr. HNE-induced pulmonary hemorrhage was inhibited by a single bolus i.v. injection of MDL 101,146 (ED50 of 0.5 mg/kg); the duration of action of the compound (10 mg/kg i.v.) was between 60 and 120 min. Intratracheal administration of MDL 101,146 inhibited HNE-induced pulmonary hemorrhage with an ED50 of 0.5 microgram/hamster (5 microgram/kg) and a duration of action of between 6 and 18 hr. MDL 101,146 inhibited HNE-induced pulmonary hemorrhage by 75% when administered as a single i.v. bolus after lung hemorrhage had occurred.
"
3.
Experimental Arthritis
12/01/1997 - "
Histological evaluation demonstrated a bone and cartilage sparing effect of MDL 101,146 in the tibio-tarsal joint of animals with collagen-induced arthritis.
"
12/01/1997 - "
MDL 101,146 administered orally inhibited the severity of collagen-induced arthritis as measured by a reduction in clinical score and joint swelling.
"
12/01/1997 - "
Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146.
"
12/01/1997 - "
The neutrophil elastase inhibitor MDL 101,146 was examined for its anti arthritic effect and to determine the role of neutrophil elastase in collagen-induced arthritis and adjuvant arthritis.
"
Related Drugs and Biologics
1.
Secretory Proteinase Inhibitory Proteins
2.
Leukocyte Elastase (Neutrophil Elastase)
3.
Thermolysin
4.
Polymers
5.
Dihydrotachysterol (AT 10)
Related Therapies and Procedures
1.
Oral Administration