lipine

02/01/2006 - "Recent studies in the mouse have demonstrated that variations in lipin expression levels in adipose tissue have marked effects on adipose tissue mass and insulin sensitivity. "
07/01/2014 - "Most of the observed changes might be a consequence of elevated expression and altered localization of lipin 1. Increased inhibitory phosphorylation of IRS-1 is possible link between cardiac lipid metabolism and insulin resistance in FFR."
12/01/2008 - "Lipin 1beta regulates lipid metabolism and augments insulin sensitivity. "
01/01/2007 - "The mouse lipin gene, Lpin1, is important for adipose tissue development and is a candidate gene for insulin resistance. "
10/01/2008 - "Collectively, these studies reveal new and unexpected effects of lipin 1 on hepatic TAG metabolism and obesity-related hepatic insulin resistance."

03/01/2007 - "The objective of this study was to determine whether altered lipin gene expression is associated with HIV lipodystrophy in humans. "
12/01/2012 - "We observed that the lipin 1 inactivation in adipocytes of aP2(Cre/+)/Lp(fEx2)(-)(3/fEx2)(-)(3) mice resulted in lipodystrophy and the presence of adipocytes with multilocular lipid droplets. "
03/01/2007 - "Based on the demonstrated role for lipin in promoting lipogenic gene expression, these observations raise the possibility that variations in lipin levels may contribute to variations in adipose tissue mass and function that distinguish HIV patients with and without lipodystrophy."
03/01/2007 - "Unexpectedly, however, this was explained by an increase in lipin-beta expression in HIV patients without lipodystrophy compared to patients with lipodystrophy and control subjects. "
03/01/2007 - "Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy."

01/22/2002 - "Lipin is the product of the gene that is mutated in fatty liver dystrophy (fld) mice [Peterfy, M., Phan, J., Xu, P. "
04/01/2011 - "Loss of lipin 1 in the mouse, but not in humans, leads to lipodystrophy and fatty liver disease. "
01/01/2011 - "The gene encoding lipin 1 was identified with a positional cloning approach that localized the causative mutation in fatty liver dystrophic (fld) mice, a mouse model of lipodystrophy. "
11/01/2007 - "Lpin1 was identified as the mutated gene in the fatty liver dystrophy mouse, which exhibits lipin deficiency and features of human lipodystrophy. "
12/01/2006 - "The lipin-deficient fatty liver dystrophy (fld) mouse is an exception, as there is lipodystrophy without a fatty liver. "

07/15/2012 - "We conclude that direct control of lipin 1 transcription by HIF-1 is an important regulatory feature of lipid metabolism and its adaptation to hypoxia."
12/01/2006 - "Use of Cerebrokurin and lipin in animals which underwent moderate hypoxia lead to probable increase in mitochondria area in the unit of volume in comparison with animals not treated with these agents."
12/01/2006 - "The authors carried out the sudy on morphofunctional changes of mitochondria of neurocytes of the brainstem of rats under experimental model of hypoxia and administration of Cerebrokurin and lipin. "
12/01/2006 - "[Effect of cerebrokurin and lipin on changes in the rat brain mitochondria in experimental model of hypoxia]."
07/01/1993 - "It is concluded that the organism tissues in the presence of liposomas do not practically suffer from the oxygen deficiency and introduction of lipin may be effective to prevent from development of the secondary tissue hypoxia."

06/01/2011 - "Our results show that, in PCOS patients, intron 1 SNP is protective against IR and glucose intolerance suggesting that lipin 1 variation could be one of the genetic factors in cardiometabolic complications of PCOS."
10/01/2006 - "To assess lipin expression and its relation to insulin resistance in humans, we examined lipin-alpha and -beta mRNA levels in subjects with normal or impaired glucose tolerance. "
10/01/2006 - "When compared with normal glucose-tolerant subjects, individuals with impaired glucose tolerance were more insulin resistant, demonstrated higher levels of intramyocellular lipids (IMCLs), and expressed approximately 50% lower levels of lipin-alpha and -beta. "