GR 94800

a selective NK2 heptapeptide antagonist

Also Known As:

GR-94800; GR94800; N-alpha-benzoyl-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2; N-alpha-benzoylalanyl-alanyl-tryptophyl-phenylalanyl-prolyl-prolyl-norleucinamide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - GR 94800: 1

Experts

1.	Cury, Yara: 1 article (04/2003)
2.	Zanchet, Eliane Maria: 1 article (04/2003)

Related Diseases

Hyperalgesia

04/25/2003 - "Hyperalgesia was significantly inhibited by N-[2-(4-chlorophenyl) ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide (capsazepine), a vanilloid receptor antagonist, by the local administration of pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Pro (spiro-gamma-lactam) Leu-Trp-NH(2) (GR82334) or of Phenyl-CO-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH(2) (GR94800), inhibitors of tachykinin NK(1) and NK(2) receptors, respectively, or by the local injection of dizocilpine (MK 801), (+/-)-2-amino-5-phosphonopentanoic acid ((+/-)-AP-5), or 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), antagonists of NMDA and non-NMDA excitatory amino acid receptors. "

Related Drugs and Biologics

1.	TRPV Cation Channels
2.	6-Cyano-7-nitroquinoxaline-2,3-dione (6 Cyano 7 nitroquinoxaline 2,3 dione)
3.	Neurokinin-2 Receptors (Neurokinin 2 Receptor)
4.	Glutamate Receptors (Glutamate Receptor)
5.	Dizocilpine Maleate (Dizocilpine)
6.	N-Methylaspartate (NMDA)
7.	2-Amino-5-phosphonovalerate (2 Amino 5 phosphonovalerate)
8.	Tachykinins
9.	Lactams
10.	tyrosyl-proline (Tyr-Pro)