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EMD 60400

a kappa-opioid receptor agonist; structure given in first source

Also Known As:

EMD-60400; N-methyl-N-(1-phenyl-2-(3-hydroxypyrrolidine-1-yl)ethyl)-2-aminophenylacetamide dihydrochloride

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - EMD 60400: 1

Related Diseases

1.	Neurogenic Inflammation 03/01/1994 - "The peripheral actions of systemically-applied EMD 60400 against hyperalgesic pressure pain and neurogenic inflammation are very probably mediated by opioid receptors on the endings of sensory nerve fibres."
2.	Pain (Aches) 03/01/1994 - "The peripheral actions of systemically-applied EMD 60400 against hyperalgesic pressure pain and neurogenic inflammation are very probably mediated by opioid receptors on the endings of sensory nerve fibres." 03/01/1994 - "Furthermore, EMD 60400 was considerably more potent in the rat pressure pain test after the induction of inflammation with carrageenin than under normalgesic conditions (ID50 values 0.1 Microg kg-1 and 4.0 mg kg-1, s.c., respectively). " 03/01/1994 - "The action of EMD 60400 (50 microgkg-1, s.c.) in the hyperalgesic pressure pain test was completely antagonized by injection of the K-opioid antagonist, norbinaltorphimine (100 microg) into the inflamed tissue, thus demonstrating the peripheral opioid nature of this effect.8. EMD 60400 produced dose-dependent inhibition of neurogenic plasma extravasation elicited byantidromic electrical stimulation of the rat saphenous nerve (ID50 value 0.3 mg kg-1, i.v.). "
3.	Inflammation (Inflammations) 03/01/1994 - "Furthermore, EMD 60400 was considerably more potent in the rat pressure pain test after the induction of inflammation with carrageenin than under normalgesic conditions (ID50 values 0.1 Microg kg-1 and 4.0 mg kg-1, s.c., respectively). "

Related Drugs and Biologics

1.	Opioid Receptors (Opioid Receptor)
2.	Narcotic Antagonists (Opioid Antagonists)
3.	Carrageenan
4.	Opioid Analgesics (Opioids)
5.	norbinaltorphimine