|1.||Laufer, Stefan: 10 articles (08/2012 - 07/2002)|
|2.||Martel-Pelletier, Johanne: 7 articles (08/2011 - 07/2002)|
|3.||Pelletier, Jean-Pierre: 7 articles (08/2011 - 07/2002)|
|4.||Steele, Vernon E: 6 articles (10/2015 - 08/2011)|
|5.||Mohammed, Altaf: 5 articles (10/2015 - 12/2011)|
|6.||Rao, Chinthalapally V: 5 articles (10/2015 - 12/2011)|
|7.||Martel-Pelletier, J: 5 articles (06/2009 - 10/2001)|
|8.||Laufer, S: 5 articles (06/2009 - 10/2001)|
|9.||Janakiram, Naveena B: 4 articles (10/2015 - 12/2011)|
|10.||Kumar, Anil: 4 articles (01/2012 - 10/2010)|
09/01/2015 - "Licofelone is a COX/5-LOX inhibitor, which recently was approved as an effective treatment for osteoarthritis. "
04/01/2004 - "Further trials will be required to investigate the safety and efficacy of licofelone in the treatment of diseases such as osteoarthritis."
04/28/2007 - "Efficacy of licofelone in dogs with clinical osteoarthritis."
01/01/2008 - "Licofelone: the answer to unmet needs in osteoarthritis therapy?"
01/01/2007 - "Activity and potential role of licofelone in the management of osteoarthritis."
08/01/2011 - "Knee osteoarthritis patients from a 2-year clinical trial evaluating licofelone versus naproxen were investigated for the incidence of TKR of the study knee. "
06/01/2009 - "In a multicentre study to explore the effects of licofelone as a disease-modifying osteoarthritis drug in comparison with naproxen in patients with knee osteoarthritis (OA), using MRI and x-ray examination. "
12/01/2010 - "To assess in a multicentre randomised double-blind phase III clinical trial evaluating the effect of licofelone in comparison with naproxen on knee osteoarthritis (OA) the presence of, and change in, bone marrow lesions (BML) over time, their relationship to cartilage volume loss, meniscal extrusion and pain. "
06/01/2009 - "Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI."
|3.||Lung Neoplasms (Lung Cancer)
08/01/2011 - "This study evaluated the chemopreventive efficacy and mechanism of licofelone, a dual inhibitor of COX-2 and 5-lipoxygenase (5-Lox), via oropharyngeal aspiration against mouse lung adenoma. "
08/01/2011 - "In conclusion, this study showed that licofelone via aspiration showed chemopreventive efficacy against mouse lung adenoma with good correlation to early and late biomarkers of lung cancer progression. "
01/01/2008 - "Available clinical data have shown that licofelone is at least as effective as the conventional nonsteroidal anti-inflammatory drugs or coxibs in ameliorating the symptoms of OA, but it may offer the advantage of improved gastrotolerability and fewer or no incidences of worsened peripheral edema. "
|1.||Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
|2.||Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
|5.||Biological Markers (Surrogate Marker)
|6.||Caspase 3 (Caspase-3)
|7.||Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
|8.||Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
|10.||1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)