safranal

01/01/2021 - "Safranal's in vivo effects were further supported in HepG2 cells where apoptosis was induced and inflammation was downregulated. "
01/01/2015 - "It was ascertained that, compared to the diabetic group, safranal decreased the inflammation both in the plasma and pancreas tissue, by reducing the TNF-α and IL-1β levels in particular. "
01/01/2019 - "This study elucidates the anti-inflammation activity of Safranal, which may be a candidate for inflammatory bowel syndrome (IBD) therapy."
01/01/2015 - "It was concluded that safranal might be helpful in terms of reduction of diabetic complications, by means of its effects on both oxidative stress and inflammation, and that further studies should be carried out for this purpose. "
08/01/2015 - "The aim of this study is to investigate the curative and renal damage-reducing effects of safranal on inflammation and oxidative stress in diabetic nephropathy. "

05/01/2015 - "Safranal at the doses of (0.1 and 0.3 ml/kg) but not 0.5 ml/kg attenuated duration and intensity of tremor. "
05/01/2015 - "Both aqueous and ethanolic extracts of saffron and with a less effect, low doses of safranal, have relatively protective and suppressive effects on the harmaline-induced tremor and different constituents of extracts seem to participate in the protective effects against harmaline induced tremor."
05/01/2015 - "Onset of tremor increased with the extracts (80 and 160 mg/kg) in prophylactic study, as the effect observed with propranolol at the dose of 5 mg/kg. Safranal did not affect the latency of tremor. "
05/01/2015 - "Test groups were also given the aqueous and ethanolic extracts of saffron (40, 80, and 160 mg/kg) as well as safranal (0.1, 0.3, and 0.5 ml/kg), intraperitoneally, 10 min before harmaline administration (prophylactic study) or 10 min after the onset of tremors (curative study). "
05/01/2015 - "Effect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice."

09/01/2012 - "Akt/GSK-3β/eNOS phosphorylation arbitrates safranal-induced myocardial protection against ischemia-reperfusion injury in rats."
01/01/2017 - "This study concluded that safranal had protective effects on ischemic reperfusion injury in the rat model of stroke. "

01/01/2021 - "Safranal exhibits anti-cancer property and the present study explores its antiangiogenic property. "
12/01/2013 - "In the present study, anti-tumor effects of safranal, the major aromatic compound in saffron, and its liposomal form were investigated. "
01/01/2020 - "Safranal suppressed the tumor growth of quiescent Pca cell xenografts in vivo. "
05/01/2018 - "The results revealed that safranal suppressed the proliferation of colo-205 cancer cells with an IC50 of 20 μM. "
08/05/2015 - "Safranal, a component of saffron, indicates anti-tumor activities; however, the precise mechanism of this effect has remained elusive. "

01/01/2013 - "Our findings might raise a possibility of potential therapeutic application of safranal for preventing and treating neurodegenerative disorders such as Alzheimer's disease."
07/23/2014 - "This study concludes that safranal and crocin represent useful leads for the discovery of novel hMAO inhibitors for the clinical management of psychiatric and neurodegenerative disorders."
06/01/2021 - "Safranal, an organic compound isolated from saffron, has been reported to have anti-apoptotic, anti-inflammatory and antioxidant activity and has studied in chronic and neurodegenerative disease. "
01/01/2023 - "According to our review, most of the studies are related to the safranal effects on CNS such as antianxiety, analgesic, anticonvulsant, antiischemic, anti-tremor, memory enhancement and its protective effects on neurodegenerative disorders such as Alzheimer's, Parkinson and Huntington diseases. "
01/01/2013 - "The present study demonstrated that a combination of safranal + curcumin + thymoquinone can block GSD-induced cell death and has the potential to be considered for management of cerebral ischemia and neurodegenerative diseases."