bufadienolide

01/14/2019 - "These may play important roles in the cardiotoxicity of bufadienolide-like chemicals. "
01/14/2019 - "This work used bioinformatics analysis to study this mechanism via gene expression profiles of bufadienolide-like chemicals: (1) Differentially expressed gene identification combined with gene set variation analysis, (2) similar small -molecule detection, (3) tissue-specific co-expression network construction, (4) differentially regulated sub-networks related to breast cancer phenome, (5) differentially regulated sub-networks with potential cardiotoxicity, and (6) hub gene selection and their relation to survival probability. "
10/15/2022 - "The administration of Digifab helped to reverse the bufadienolide cardiac toxicity."
11/01/2018 - "Arenobufagin is a naturally occurring bufadienolide showing promising antitumor activity accompanied however with apparent cardiac toxicity. "
01/01/2012 - "Pretreatment with taurine (150, 300 mg/kg) significantly prevented bufadienolide-induced cardiotoxicity and reduced the mortality in vivo. "

12/01/2019 - "Bufadienolide compounds have been used for growth inhibition and apoptosis induction in tumor cells. "
10/01/2015 - "Research shows that the main anti-tumor components in bufadienolide. "
06/28/2013 - "Structure-activity relationship analysis of bufadienolide-induced in vitro growth inhibitory effects on mouse and human cancer cells."
09/01/2001 - "In addition, bufadienolide 1 was found active against the MH-60 cancer cell line."
11/15/2020 - "Research advancements regarding bufadienolide prodrugs and their tumor-targeting delivery strategies are critically summarized. "

01/01/2018 - "Here, we report that resibufogenin, a member of bufadienolide family, suppresses the growth and metastasis of colorectal cancer (CRC) through induction of necroptosis in vivo. "
06/28/2023 - "A 24-h marinobufagin-induced acute toxicity included signals of central activity, mainly (vocal frenzy, absence of body tonus, increased ventilation, ataxia, and equilibrium loss), and convulsions and death at 10 mg/kg. The bufadienolide presented effective in vitro cytotoxic action on human lines of colorectal carcinomas in a similar way to ouabain and tumor reduction in marinobufagin-treated SCID-bearing HCT-116 heterotopic xenografts. "

06/01/1999 - "Digoxin specific Fab fragments are effective in the treatment of Chan Su poisoning in mice and may be effective for poisoning by other cardioactive steroids of the bufadienolide class."

02/01/2013 - "Although verapamil reduced the bufadienolide-induced ventricular arrhythmias, verapamil worsened heart block and lethal bradycardia of bufadienolides partly via increasing the uptake of bufadienolides in heart tissue, which could compromise the protective effects of verapamil against bufadienolide intoxication. "