protein kinase C gamma (PRKCG)

calcium-dependent isoenzyme of protein kinase C; mutation of PKCgamma can lead to spinocerebellar ataxia type 14 (SCA14); amino acid sequence has been determined
Also Known As:
PRKCG; PKC(gamma); SCA14 PKCgamma protein, human; protein kinase C(gamma); protein kinase C-gamma
Networked: 110 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Jarius, S: 3 articles (01/2015 - 01/2015)
2. Wildemann, B: 3 articles (01/2015 - 01/2015)
3. Verbeek, Dineke S: 3 articles (03/2014 - 06/2005)
4. Sakai, Norio: 3 articles (09/2011 - 09/2006)
5. Seki, Takahiro: 3 articles (09/2011 - 09/2006)
6. Saito, Naoaki: 3 articles (09/2011 - 11/2002)
7. Sinke, Richard J: 3 articles (07/2008 - 06/2005)
8. Klockgether, Thomas: 2 articles (08/2015 - 02/2014)
9. Minnerop, Martina: 2 articles (08/2015 - 02/2014)
10. Goedhart, Joachim: 2 articles (03/2014 - 07/2008)

Related Diseases

1. Hyperalgesia
2. Neoplasms (Cancer)
10/15/1994 - "Therapy with adoptively transferred PKC-gamma-transduced T cell clones and lines into syngeneic mice, with or without FBL-3 tumor, showed that the PKC-gamma-transduced T cells were not tumorigenic and were effective in curing mice with disseminated FBL-3."
12/01/1994 - "PKC gamma was expressed at a very low level in two of the colon tumors but could not be detected in the remaining tumors or any of the normal mucosa samples. "
07/30/2013 - "The main biological networks of HMs with cold and hot properties include cell cycle, cellular growth, proliferation and development, cancer, cytokine signaling, and intracellular and second messenger signaling; 11 specific pathways are presented to be perturbed only by HMs with the hot property, and the 27 specific target protein molecules include PRKACA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKD1, TLR4, TLR7, TLR8, TLR9, HTR4, HTR6, HTR7, HTR2A, HTR1B, HTR2B, GNAO1, GNAI1, TNF, IL8, ROCK2, AKT1, MAPK1, RPS6KA1, RPS6KA3 and JAK2, which are involved in the biological network. "
12/01/1994 - "Fifteen minutes following topical treatment with a tumor promoting dose of TPA (3.4 nmol), the activities of PKC beta and PKC gamma decreased in the epidermal cytosol to 30% and 50% of control values, respectively, while these activities were increased in the epidermal particulate fraction by approximately 50%. "
01/01/1991 - "In this report, we show that transient expression of the PKC gamma isoenzyme can trans-activate a murine VL30 enhancer element in a pattern similar to that of the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate. "
3. Spinocerebellar Ataxias (Spinocerebellar Ataxia)
4. Osteosarcoma (Osteogenic Sarcoma)
5. Ataxia (Dyssynergia)

Related Drugs and Biologics

1. protein kinase C beta
2. protein kinase C gamma (PRKCG)
3. Calcium
4. Complementary DNA (cDNA)
5. Freund's Adjuvant
6. Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
7. Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
8. Carrier Proteins (Binding Protein)
9. Protein Kinase C-epsilon
10. Phosphotransferases (Kinase)

Related Therapies and Procedures

1. Ligation
2. Analgesia