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palmitoyl rhizoxin
structure in first source
Also Known As:
RS 1541; RS-1541; Rhizoxin, 13-hexadecanoate
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Lactones: 1549
palmitoyl rhizoxin: 6
Related Diseases
1.
Neoplasms (Cancer)
02/01/1996 - "
The levels of RS-1541 in the plasma and tissues including tumor, were determined by HPLC.
"
01/01/1995 - "
Intracellular activation and cytotoxic action of RS-1541 against cultured human tumor cells.
"
03/01/1995 - "
These results indicate that RS-1541 possesses a high tumor-selective effect compared with rhizoxin, because of the selective production of rhizoxin in the tumor after administration of RS-1541.
"
03/01/1995 - "
After administration of RS-1541, no significant amounts of rhizoxin were detected in the tissues, except for the tumor.
"
01/01/1995 - "
RS-1541 has been shown to bind preferentially to plasma lipoproteins and to exhibit selective and sustained uptake by tumors in mice.
"
2.
Sarcoma (Soft Tissue Sarcoma)
05/01/1996 - "
The concentrations of RS-1541 in tumour tissues after an intravenous administration of ODO/HCO-60 emulsions of RS-1541 to mice bearing solid tumour M5076 sarcoma were about ten times higher than those after the administration of SOY/LEC emulsions.
"
03/01/1995 - "
Tumor selective effect of RS-1541 (palmitoyl-rhizoxin) in M5076 sarcoma and host tissues in vivo.
"
03/01/1994 - "
The tumour uptake as well as the anti-tumour activity of RS-1541 (palmitoyl rhizoxin), a potent antineoplastic agent, were investigated in mice bearing M5076 sarcoma.
"
03/01/1995 - "
After intravenous administration of RS-1541 to mice bearing M5076 sarcoma, the maximal inhibitory effect of RS-1541 on DNA synthesis in the tumor was observed 24 h after administration, in agreement with the Cmax of rhizoxin produced from RS-1541, but not with the Cmax of RS-1541.
"
3.
Stomach Neoplasms (Stomach Cancer)
01/01/1995 - "
Delivery and cytotoxicity of RS-1541 in St-4 human gastric cancer cells in vitro by the low-density-lipoprotein pathway.
"
01/01/1995 - "
To elucidate a mechanism of RS-1541 cytotoxicity, the cellular uptake and the cytotoxicity of a complex of RS-1541 with human low-density lipoprotein (RS-1541/LDL complex) were investigated in cultured St-4 human gastric cancer cells.
"
Related Drugs and Biologics
1.
palmitoyl rhizoxin
2.
Emulsions
3.
Solutions
4.
LDL Lipoproteins (beta Lipoproteins)
5.
Lipoproteins (Lipoprotein)
6.
Lipids
7.
DNA (Deoxyribonucleic Acid)
8.
Antineoplastic Agents (Antineoplastics)
9.
oxidized low density lipoprotein
10.
rhizoxin
Related Therapies and Procedures
1.
Intravenous Administration