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7-hydroxywarfarin

a warfarin metabolite

Also Known As:

2H-1-Benzopyran-2-one, 4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)-

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        4-Hydroxycoumarins: 2
        Warfarin: 13728
        7-hydroxywarfarin: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        4-Hydroxycoumarins: 2
        Warfarin: 13728
        7-hydroxywarfarin: 5

Experts

1.	Cheng, Gregory: 1 article (06/2010)
2.	Lo, Cindy M Y: 1 article (06/2010)
3.	Wo, Siu Kwan: 1 article (06/2010)
4.	You, Joyce H S: 1 article (06/2010)
5.	Zhou, Limin: 1 article (06/2010)
6.	Zuo, Zhong: 1 article (06/2010)
7.	Cho, Hyun-Jung: 1 article (12/2009)
8.	Kim, Hee-Jin: 1 article (12/2009)
9.	Kim, Jong-Won: 1 article (12/2009)
10.	Kim, June-Soo: 1 article (12/2009)

Related Diseases

1.	Cystic Fibrosis (Mucoviscidosis) 09/01/1993 - "The metabolic clearance of (S)-warfarin to its major metabolites mediated by CYP2C9, 6-hydroxywarfarin and 7-hydroxywarfarin, was not significantly (p > 0.05) different between the two groups (6-hydroxywarfarin: subjects with cystic fibrosis, 0.33 +/- 0.1 ml/hr/kg; control subjects, 0.41 +/- 0.1 ml/hr/kg; 7-hydroxywarfarin: subjects with cystic fibrosis, 1.34 +/- 0.49 ml/hr/kg; control subjects, 1.8 +/- 0.45 ml/hr/kg). " 05/01/1994 - "The unbound metabolic clearances of (R)-warfarin to its oxidative metabolites--6-hydroxywarfarin, 7-hydroxywarfarin, 8-hydroxywarfarin, and 10-hydroxywarfarin (mediated by P450 3A4)--were also similar (p > 0.05) in the two groups (6-hydroxywarfarin: cystic fibrosis: 124.2 +/- 72.8 ml/hr/kg, control: 99.4 +/- 37.3 ml/hr/kg; 7-hydroxywarfarin: cystic fibrosis: 43.8 +/- 32.2 ml/hr/kg, control: 34.5 +/- 10.6 ml/hr/kg; 8-hydroxywarfarin: cystic fibrosis: 80.4 +/- 85.4 ml/hr/kg, control: 69.5 +/- 39.5 ml/hr/kg; 10-hydroxywarfarin: cystic fibrosis: 4.38 +/- 2.72 ml/hr/kg, control: 16.28 +/- 13.71 ml/hr/kg). "
2.	Hemorrhage 06/05/2010 - "Determination of warfarin enantiomers and their enantiomeric 7-hydroxywarfarin (7-OH-warfarin) metabolites in the human plasma sample allows probing of cytochrome P450 isoenzyme activities and detection of ingestion of warfarin-containing products for the investigation of unexplained bleeding. "
3.	Heart Diseases (Heart Disease) 12/01/1999 - "Warfarin enantiomers and benzbromarone in serum, 7-hydroxywarfarin in urine, and serum unbound fractions of warfarin enantiomers were measured in patients with heart disease given warfarin with (n = 13) or without (n = 18) oral benzbromarone (50 mg/d). "
4.	Atrial Fibrillation 12/01/2009 - "We included a total of 105 patients with atrial fibrillation, and who were receiving warfarin for more than 1 yr. The plasma concentrations of total warfarin and 7-hydroxywarfarin were determined by HPLC-MS/MS (Waters, UK). "

Related Drugs and Biologics

1.	Warfarin (Coumadin)
2.	Cytochrome P-450 CYP2C9
3.	6-hydroxywarfarin
4.	Isoenzymes
5.	Cytochrome P-450 Enzyme System (Cytochrome P450)
6.	Benzbromarone
7.	8-hydroxywarfarin
8.	10-hydroxywarfarin