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AG 331

structure given in second source

Also Known As:

AG-331; N(6)-(4-(N-morpholinosulfonyl)benzyl)-N(6)-methyl-2,6-diaminobenz(cd)indole glucuronate

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - AG 331: 3

Related Diseases

1.	Neoplasms (Cancer) 04/21/1995 - "Intra-day coefficient of variation was less than 9.5%, and inter-day coefficient of variation was less than 14.3% for an AG-331 concentration of 44 ng/ml. This method has been used to characterize the pharmacokinetics of AG-331 in cancer patients as part of ongoing Phase I trials." 04/21/1995 - "High-performance liquid chromatographic method for the determination of AG-331, a novel anti-cancer agent, in human serum and urine using solid-phase extraction and photodiode-array detection." 01/01/1999 - "Phase I study of AG 331, a novel thymidylate synthase inhibitor, in patients with refractory solid tumors."
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/1994 - "Similar results were also obtained in protection experiments with a human hepatoma cell line, HEPG2, although previous results obtained in colon- and breast-cancer cell lines have suggested TS specific effects for AG-331. " 01/01/1994 - "There was no evidence for any intracellular effect of AG-331 on dihydrofolate reductase (DHFR); however, the low degree of cross-resistance found for the H35FF line, which has elevated TS levels, suggested that TS may not be the sole locus of action of AG-331 in hepatoma cells. "
3.	Breast Neoplasms (Breast Cancer) 01/01/1994 - "Similar results were also obtained in protection experiments with a human hepatoma cell line, HEPG2, although previous results obtained in colon- and breast-cancer cell lines have suggested TS specific effects for AG-331. "

Related Drugs and Biologics

1.	Thymidylate Synthase
2.	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)