N- acetylglucosaminyl- phosphatidylinositol de-N-acetylase

involved in formation of glycosylphosphatidyl inositol membrane anchors in Trypanosoma brucei; forms glucosaminyl-phosphatidylinositol

Also Known As:

GlcNAc-PI de-N-acetylase; N-acetylglucosaminyl-phosphatidylinositol deacetylase

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

1.	Ferguson, Michael A J: 3 articles (03/2014 - 06/2005)
2.	Urbaniak, Michael D: 3 articles (03/2014 - 06/2005)
3.	Crossman, Arthur: 2 articles (03/2014 - 06/2005)
4.	Rashmi, Mayank: 1 article (12/2015)
5.	Swati, D: 1 article (12/2015)
6.	Capes, Amy S: 1 article (03/2014)
7.	Gilbert, Ian H: 1 article (03/2014)
8.	O'Neill, Sandra: 1 article (03/2014)
9.	Thompson, Stephen: 1 article (03/2014)
10.	Abdelwahab, Nuha Z: 1 article (03/2012)

1.	Thymoma (Thymic Carcinoma) 04/16/2004 - "Previous studies of mouse thymoma cells showed that GlcNAc-PI de-N-acetylase activity is localized to the endoplasmic reticulum (ER) but enriched in a mitochondria-associated ER membrane (MAM) domain. " 04/16/2004 - "We show that human PIG-L is a type I membrane protein with a large cytoplasmic domain and that, unlike the result with mouse thymoma cells, both PIG-L and GlcNAc-PI-de-N-acetylase activity are uniformly distributed between ER and MAM in HeLa cells. "
2.	African Trypanosomiasis (Nagana) 12/01/2015 - "In silico drug re-purposing against African sleeping sickness using GlcNAc-PI de-N-acetylase as an experimental target." 03/31/2014 - "The zinc-metalloenzyme GlcNAc-PI de-N-acetylase is essential for the biosynthesis of mature GPI anchors and has been genetically validated in the bloodstream form of Trypanosoma brucei, which causes African sleeping sickness. " 03/01/2012 - "Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness." 06/17/2005 - "Glycosylphosphatidylinositol biosynthesis is essential for Trypanosoma brucei, the causative agent of African sleeping sickness, and GlcNAc-PI de-N-acetylase has previously been validated as a drug target. "

1.	Zinc
2.	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)
3.	Membrane Proteins (Integral Membrane Proteins)