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nitrofenac

a diclofenac-derivative containing the nitric oxide group; structure given in first source

Also Known As:

2-((2,6-dichlorophenyl) amino)benzeneacetate-4-hydroxybutylnitric ester; Nitrofenac

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phenylacetates: 3
      - Diclofenac: 4384
        nitrofenac: 5

Related Diseases

1.	Ulcer 08/01/1995 - "This study was performed to determine if one of these compounds (nitrofenac) would influence healing of a preexisting ulcer. "
2.	Arthritis (Polyarthritis) 01/01/1994 - "Daily oral administration of diclofenac and nitrofenac at 3 mg kg-1 markedly and significantly inhibited arthritis development until the end of the study period. "
3.	Stomach Ulcer (Gastric Ulcer) 05/23/1994 - "The diclofenac derivative, 'nitrofenac', was examined in terms of its ability to induce acute gastric erosions and chronic-type gastric ulcers in rats and rabbits, respectively. " 11/01/1993 - "The lack of the gastric ulcers in rats treated with nitrofenac could be due to the absorption of the drug as an inactive inhibitor of PG synthesis and/or to the fact that probably nitric oxide is released in the intestine and plays an important protective role in maintaining the tissue integrity." 08/01/1995 - "Seven days after induction of gastric ulcer with serosal acetic acid, daily oral treatment with antiinflammatory doses of diclofenac, nitrofenac, or vehicle was started. "
4.	Inflammation (Inflammations) 05/23/1994 - "Diclofenac and nitrofenac exerted similar inhibitory effects on prostaglandin E2 synthesis in the stomach and in a carrageenan-sponge model of peripheral inflammation. "
5.	Hyperemia 01/01/1994 - "No deaths were observed in the rats treated with nitrofenac, and the only small intestinal abnormality observed was diffuse hyperemia. "

Related Drugs and Biologics

1.	Diclofenac (SR 38)
2.	Acetic Acid (Vinegar)
3.	Dinoprostone (PGE2)
4.	Sulfonic Acids
5.	Nitric Oxide (Nitrogen Monoxide)
6.	Carrageenan

Related Therapies and Procedures

1.	Oral Administration