macrogolgin

a 376 kDa Golgi complex outer membrane protein; a target of antibodies in patients with Rheumatic diseases & HIV infections; a golgin

Also Known As:

GOLGB1 protein, human; Golgb1 protein, mouse; Golgb1 protein, rat; Golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1; giantin; giantin protein, human; golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 protein, human; golgi autoantigen, golgin subfamily b, macrogolgin 1, mouse

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Golgi Matrix Proteins: 36
    - macrogolgin: 15

Experts

1.	Bergen, Dylan J M: 3 articles (01/2021 - 08/2017)
2.	Stephens, David J: 3 articles (01/2021 - 08/2017)
3.	Stevenson, Nicola L: 3 articles (01/2021 - 08/2017)
4.	Hammond, Chrissy L: 2 articles (01/2021 - 12/2017)
5.	Bhat, Ganapati: 2 articles (01/2020 - 11/2017)
6.	Cheng, Pi-Wan: 2 articles (01/2020 - 11/2017)
7.	Katayama, Kentaro: 2 articles (01/2018 - 11/2011)
8.	Suzuki, Hiroetsu: 2 articles (01/2018 - 11/2011)
9.	Skinner, Roderick E H: 2 articles (12/2017 - 08/2017)
10.	Kadler, Karl E: 1 article (01/2021)

Related Diseases

1.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2023 - "In the present study, we depleted PKM2 expression using RNA interference (RNAi), which induced apoptotic cell death and was accompanied by the downregulation of GM130, giantin, and p115 in HeLa and ME-180 cervical cancer cells. "
2.	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 11/01/2011 - "Therefore, we concluded that mutation of the Golgb1 gene is responsible for the phenotypic characteristics including osteochondrodysplasia of ocd/ocd, and that giantin plays a pivotal role in multiple aspects of chondrogenesis." 08/15/2017 - "Loss of function of giantin in rats causes osteochondrodysplasia; knockout mice show milder defects, notably a cleft palate. " 01/01/2018 - "An insertion mutation in the Golgb1 gene, resulting in a lack of giantin protein expression, has been detected in ocd/ocd rats that exhibit a pleiotropic phenotype including osteochondrodysplasia. " 01/01/2018 - "These findings suggest that giantin plays a pivotal role in coordinated production of aggrecan, link protein and type XI collagen in chondrocytes, and that loss of giantin causes osteochondrodysplasia with disturbance of these ECM components."
3.	Prostatic Neoplasms (Prostate Cancer) 11/01/2017 - "Defective giantin in androgen-independent prostate cancer cells results in a shift of Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65. " 11/01/2017 - "In situ proximity ligation assays of Golgi localization of α-mannosidase IA at giantin versus GM130-GRASP65 site, and absence or presence of N-glycans terminated with α3-mannose on trans-Golgi glycosyltransferases may be useful for distinguishing indolent from aggressive prostate cancer cells." 11/01/2017 - "Shifted Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65 results in formation of high mannose N-glycans in aggressive prostate cancer cells." 01/01/2020 - "Recently, we discovered that loss of giantin function as the primary Golgi targeting site for endoplasmic reticulum-derived transport vesicles in aggressive prostate cancer cells caused a shift of the Golgi localization site of α-mannosidase 1A to 130 KDa Golgi matrix protein (GM130)-65 KDa Golgi reassembly-stacking protein (GRASP65) site resulting in emergence of high mannose N-glycans on trans-Golgi enzymes and cell surface glycoproteins. "
4.	Neoplasms (Cancer) 01/01/2023 - "Altogether, our computational model identifies cell migration traits that regulate tumor progression and uncovers a role of Giantin in breast cancer progression." 01/01/2023 - "This prediction was validated, by showing that circulating tumor cells express significantly less Giantin than primary tumor cells. " 01/01/1999 - "In starved rat RBL-2H3 tumor mast cells, the GC, that was visualized at immunofluorescence level with antibodies raised against the Golgi-resident proteins giantin, mannosidase II, or TGN-38, showed a compacted morphology with a supranuclear positioning. "
5.	Vesicular Stomatitis 01/26/2001 - "Here, we show that peptides containing the GM130 or the giantin p115 binding domain and anti-GM130 and anti-giantin antibodies inhibit transport of vesicular stomatitis virus (VSV)-G protein to a mannosidase II-containing Golgi compartment. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Antibodies
3.	Polysaccharides (Glycans)
4.	Membrane Proteins (Integral Membrane Proteins)
5.	Mannosidases
6.	Mannose (D-Mannose)
7.	Golgi Matrix Proteins
8.	mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidase
9.	Aggrecans (Aggrecan)
10.	Collagen Type XI

Related Therapies and Procedures

1.	Ligation