piclamilast

an antiasthmatic agent and phosphodiesterase 4 inhibitor; structure in first source

Also Known As:

3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide; 3-cyclopentyloxy-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide; RP 73-401; RP 73401; RP-73-401; RP-73401; benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-

Networked: 23 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Ji-Qiang: 2 articles (03/2019 - 10/2006)
2.	Tang, Hui-Fang: 2 articles (03/2019 - 10/2006)
3.	Xie, Qiang-Min: 2 articles (03/2019 - 10/2006)
4.	Boichot, Elisabeth: 2 articles (03/2005 - 04/2002)
5.	Lagente, Vincent: 2 articles (03/2005 - 04/2002)
6.	Martins, Marco A: 2 articles (03/2005 - 04/2002)
7.	Abdel-Daim, Mohamed M: 1 article (08/2022)
8.	Kaur, Amarjot: 1 article (08/2022)
9.	Khan, Heena: 1 article (08/2022)
10.	Kumar, Manish: 1 article (08/2022)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2022 - "Furthermore, postischemia administration with piclamilast, a PDE4 pan-inhibitor, improved cardiac microcirculation, suppressed inflammation, and attenuated MI/R injury in mice. " 12/01/1994 - "Furthermore, RP 73401 administered directly into the airways, protects against allergic airway inflammation. " 10/26/2006 - "This study suggests that inhibition of PDE4 by piclamilast robustly improves the pulmonary function, airway inflammation and goblet cell hyperplasia in murine allergenic asthma." 10/26/2006 - "In this study, piclamilast, a selective PDE4 inhibitor, was used to investigate the role of PDE4 in respiratory function and inflammation in a murine asthma model. " 04/01/2001 - "Interestingly, the PDE 4 inhibitor RP 73401 (100 mg kg(-1)) significantly reduced both TNF-alpha levels and neutrophilic inflammation. "
2.	Arthritis (Polyarthritis) 09/01/1998 - "For example, RP-73401 ameliorates disease severity in Streptococcal cell wall-induced arthritis in Lewis rats, a strain whose susceptibility to this disease has been attributed to a defective HPA response, without affecting either ACTH or corticosterone levels. "
3.	Asthma (Bronchial Asthma) 01/01/2004 - "Piclamilast inhibited FMLP-induced respiratory burst of sputum cells in a concentration-dependent manner (asthma: EC50 approximately 100 nM, max. " 09/22/2000 - "Our data suggest that RP 73-401 may modulate tissue remodelling associated with lung inflammatory processes including asthma." 05/01/1995 - "Thus RP 73401 is a very potent and selective PDE IV inhibitor which suppresses eosinophil function suggesting that it may be a useful agent for the treatment of inflammatory diseases such as asthma. " 05/27/1994 - "3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide (15j) showed exceptional potency in all tests and may have therapeutic potential in the treatment of asthma." 10/26/2006 - "This study suggests that inhibition of PDE4 by piclamilast robustly improves the pulmonary function, airway inflammation and goblet cell hyperplasia in murine allergenic asthma."
4.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 10/01/2004 - "Initial in vivo studies conducted in severe combined immunodeficiency mice transplanted with NB4 leukemia cells indicate that the enhancing effect of piclamilast on ATRA-induced myeloid maturation translates into a therapeutic benefit."
5.	Colorectal Neoplasms (Colorectal Cancer) 12/01/2021 - " study was designed to investigate the effect and mechanism of Piclamilast (PIC), a selective PDE4 inhibitor, on a DMH-induced colorectal cancer (CRC) rat model. "

Related Drugs and Biologics

1.	Corticosterone
2.	Adrenocorticotropic Hormone (ACTH)
3.	Phosphodiesterase 4 Inhibitors
4.	piclamilast
5.	Type 4 Cyclic Nucleotide Phosphodiesterases
6.	N- (3,5- dichloro- 4- pyrid- 4- yl)- 3- cyclopentyl- oxy- 4- methylbenzamide
7.	Transforming Growth Factor beta (TGF-beta)
8.	Poly I-C
9.	Dimenhydrinate (DMH)
10.	Imiquimod (Aldara)