2- carbomethoxy- 8- (3- fluoropropyl)- 3- (4- iodophenyl)tropane

used in PET and SPECT imaging of dopamine transporters; structure in first source

Also Known As:

(18)F-FP-CIT; (O-methyl-11C)beta-CIT-FP; 123I-FP-CIT; FP-CIT; FPCIT; I(123)-N-fluoropropyl-2-beta-carbomethoxy-3-(4-iodophenyl)nortropane; I(123)-N-omega-fluoropropyl-2-beta-carbomethoxy-3-beta(4-iodophenyl)nortropane; N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; beta-CIT-FP; fluoropropylcarbomethoxyiodophenylnortropane

Networked: 453 relevant articles (11 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Booij, Jan: 17 articles (01/2022 - 09/2002)
2.	Kaasinen, Valtteri: 11 articles (01/2022 - 01/2014)
3.	Garibotto, Valentina: 11 articles (11/2021 - 04/2015)
4.	Kim, Jae Seung: 11 articles (03/2021 - 03/2013)
5.	Joutsa, Juho: 10 articles (01/2022 - 10/2014)
6.	Booij, J: 10 articles (01/2020 - 05/2000)
7.	O'Brien, John T: 10 articles (06/2019 - 06/2004)
8.	Chung, Sun Ju: 9 articles (03/2021 - 03/2013)
9.	Oh, Minyoung: 9 articles (03/2021 - 03/2013)
10.	Ceravolo, Roberto: 9 articles (01/2021 - 12/2009)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 01/01/2019 - "F-FP-CIT PET and MRI are not helpful in distinguishing CBD from idiopathic Parkinson disease. " 11/14/2023 - "Hippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson Disease: An Early Phase 18 F-FP-CIT Positron Emission Tomography Study." 01/01/2022 - "Diagnostic value of micrographia in Parkinson's disease: a study with [123I]FP-CIT SPECT." 09/03/2021 - "The aim of this study is to evaluate various heterogeneity indices of F-18 FP-CIT PET images in the diagnosis of Parkinson's disease (PD) patients and to access the diagnostic accuracy of the indices using machine learning (ML). " 08/28/2021 - "The aim of this study was to compare the performance of a deep-learning convolutional neural network (Faster R-CNN) model to detect imaging findings suggestive of idiopathic Parkinson's disease (PD) based on [18F]FP-CIT PET maximum intensity projection (MIP) images versus that of nuclear medicine (NM) physicians. "
2.	Parkinsonian Disorders (Parkinsonism) 01/01/2018 - "A combination of cardiac 123I-meta-iodobenzylguanidine scintigraphy and 123I-FP-CIT single-photon emission computed tomography imaging, in addition to brain magnetic resonance imaging findings, helped to discriminate MSA-P from other sources of parkinsonism. " 06/01/2011 - "Improved visual [(123)I]FP-CIT SPECT interpretation for evaluation of parkinsonism by visual rating of parametric distribution volume ratio images." 05/01/2023 - "Thirty patients with newly onset parkinsonism and 32 healthy controls with both an FE-PE2I and FP-CIT were included in the study. " 12/01/2020 - "Further studies are warranted to be assessed whether using extrastriatal [123I]FP-CIT evaluation can be of help in the assessment of degenerative parkinsonism." 02/01/2020 - "The study included 41 patients (61.4 ± 12.8 years) with PD-typical reduction of striatal FP-CIT SBR and no sign of atypical parkinsonian syndrome on FDG PET. "
3.	Dementia (Dementias) 06/01/2007 - "To assess the utility of the appearances of occipital lobe perfusion on HMPAO SPECT in the diagnosis of dementia with Lewy bodies (DLB) using the 123I-FP-CIT findings as the diagnostic 'gold standard'. " 01/17/2017 - "Patients >60 years of age with dementia who had undergone 123I-FP-CIT imaging in research studies and who had donated their brain tissue to the Newcastle Brain Tissue Resource were included. " 12/15/2015 - "We searched MEDLINE, CENTRAL and ClinicalTrials.gov to identify studies reporting enough data to determine accuracy measure of 123I-FP-CIT SPECT in differentiating between DLB and other dementia syndromes. " 03/01/2012 - "A systematic meta-analysis of published studies on the diagnostic accuracy of presynaptic dopaminergic imaging with ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies (DLB). " 03/01/2012 - "Diagnostic accuracy of ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies: a meta-analysis of published studies."
4.	Movement Disorders (Movement Disorder) 01/01/2015 - "We analyzed 516 files of subjects with movement disorders who were consecutively examined using [(123)I]-FP-CIT scan and determined whether the use of imaging was appropriate and if it improved clinical diagnosis or care of the patient. " 01/01/2014 - "¹²³I-FP-CIT (DaTSCAN) SPECT studies of the nigrostriatal pathway are a valuable tool in the diagnosis of movement disorders. " 04/01/2013 - "Dopaminergic dysfunction and psychiatric symptoms in movement disorders: a 123I-FP-CIT study: reply to comment by Erro et al." 04/01/2013 - "Comment on Di Giuda et al.: Dopaminergic dysfunction and psychiatric symptoms in movement disorders: a 123I-FP-CIT SPECT study." 12/01/2012 - "Dopaminergic dysfunction and psychiatric symptoms in movement disorders: a 123I-FP-CIT SPECT study."
5.	Alzheimer Disease (Alzheimer's Disease) 11/01/2020 - "Methods:123I-FP-CIT-SPECT and neuropathologic findings among patients with neurodegenerative syndromes from the Mayo Alzheimer Disease Research Center and Mayo Clinic Study of Aging were examined. " 01/01/2020 - "Presynaptic dopaminergic function in early-onset Alzheimer's disease: an FP-CIT image study." 10/01/2020 - "Fifty-four PD patients underwent [123I]FP-CIT SPECT and CERAD (Consortium to Establish a Registry for Alzheimer's Disease) testing. " 01/01/2011 - "Positive FP-CIT SPECT (DaTSCAN) in Clinical Alzheimer's Disease - An Unexpected Finding?" 01/01/2023 - "This study provides Class II evidence that longitudinal declines in striatal uptake measured using 123[I]-FP-CIT SPECT are associated with MCI due to Lewy body disease but not MCI due to Alzheimer disease."

Related Drugs and Biologics

1.	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)
2.	3-Iodobenzylguanidine (Iobenguane)
3.	Dopamine (Intropin)
4.	3- iodo- 2- hydroxy- 6- methoxy- N- ((1- ethyl- 2- pyrrolidinyl)methyl)benzamide
5.	Levodopa (L Dopa)
6.	Biomarkers (Surrogate Marker)
7.	Ligands
8.	Antipsychotic Agents (Antipsychotics)
9.	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)
10.	Iodine

Related Therapies and Procedures

1.	Transplantation
2.	Denervation
3.	Therapeutics
4.	Gamma Cameras (Gamma Camera)
5.	Deep Brain Stimulation