DAC 1

structure in first source

Also Known As:

2(1,2-dicarba-closo-dodecaborane(12)-1(-yl-methoxy)-2-(3-aminopropyl))-1,3-propanediol; DAC-1; 1,3-Propanediol, 2-((2-(3-aminopropyl)-1,2-dicarbadodecaboran(12)-1-yl)methoxy)-

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Copeland, Amanda: 1 article (06/2011)
2.	Oki, Yasuhiro: 1 article (06/2011)
3.	Younes, Anas: 1 article (06/2011)

Related Diseases

1.	Hodgkin Disease (Hodgkin's Disease) 06/01/2011 - "Panobinostat, a potent inhibitor of DAC 1-11 enzymatic activity, has demonstrated a significant in vitro antiproliferative activity against classical Hodgkin's lymphoma (cHL) cell lines in addition to a promising clinical activity in early Phase I studies in patients with relapsed cHL. "
2.	Glioma (Gliomas) 01/01/1998 - "Uptake, toxicity and radiation effects of the boron compounds DAAC-1 and DAC-1 in cultured human glioma cells." 02/01/1994 - "New carborane-based compounds for boron neutron capture therapy: binding and toxicity of ANC-1, DAC-1 and B-Et-11-OMe in cultured human glioma and mouse melanoma cells." 02/01/1994 - "The toxicity and binding of the three new carborane based compounds: 2 (1,2-dicarba-closo-dodecaborane (12)-1(-yl-methoxy)-2-(3-amino-propyl))-1,3-propanediol, called DAC-1; 7-(3-amino-propyl)-7,8-dicarba-nido-undecarborate (-1) called ANC-1; and rac-1-(9-o-carboranyl)-nonyl-2-methyl-glycero-3- phosphocholine, called B-Et-11-OMe, were analyzed with cultured human glioma cells, U-343MGa, and mouse melanoma cells, B16, as biological models. "
3.	Neoplasms (Cancer) 02/01/1994 - "Further analysis should be made regarding biological properties such as intracellular compartmentalization, metabolic interference and tumor specificity of the compounds DAC-1 and B-Et-11-OMe."
4.	Melanoma (Melanoma, Malignant) 02/01/1994 - "New carborane-based compounds for boron neutron capture therapy: binding and toxicity of ANC-1, DAC-1 and B-Et-11-OMe in cultured human glioma and mouse melanoma cells." 02/01/1994 - "The toxicity and binding of the three new carborane based compounds: 2 (1,2-dicarba-closo-dodecaborane (12)-1(-yl-methoxy)-2-(3-amino-propyl))-1,3-propanediol, called DAC-1; 7-(3-amino-propyl)-7,8-dicarba-nido-undecarborate (-1) called ANC-1; and rac-1-(9-o-carboranyl)-nonyl-2-methyl-glycero-3- phosphocholine, called B-Et-11-OMe, were analyzed with cultured human glioma cells, U-343MGa, and mouse melanoma cells, B16, as biological models. "

Related Drugs and Biologics

1.	Panobinostat
2.	Phosphorylcholine (Phosphocholine)
3.	Boron Compounds
4.	1- (9- o- carboranyl)nonyl- 2- methyl- glycero- 3- phosphocholine
5.	ANC 1

Related Therapies and Procedures

1.	Boron Neutron Capture Therapy