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(3- dimyristyloxypropyl)(dimethyl)(hydroxyethyl)ammonium

a cationic lipid; RN refers to bromide salt
Also Known As:
DMRIE; dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium
Networked: 19 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Stopeck, A T: 2 articles (08/2001 - 09/2000)
2. Hersh, E M: 2 articles (08/2001 - 09/2000)
3. Frey, Brigitte M: 1 article (06/2011)
4. Frey, Felix J: 1 article (06/2011)
5. Gazdhar, Amiq: 1 article (06/2011)
6. Goepfert, Christine: 1 article (06/2011)
7. Pereira, C T: 1 article (12/2005)
8. Finnerty, C C: 1 article (12/2005)
9. Klein, D: 1 article (12/2005)
10. Herndon, D N: 1 article (12/2005)

Related Diseases

1. Carcinoma (Carcinomatosis)
2. Neoplasms (Cancer)
3. Melanoma (Melanoma, Malignant)
03/01/2003 - "As immunization material we compared: (1) the lysate of apoptotic or live melanoma tumor cells [MSM-M14 (M14) and MSM-M3 (M3)]; and (2) total RNA extracted from the same melanoma cell lines, either unconjugated or conjugated with a charged carrier (DMRIE-C). "
08/01/2001 - "The purpose of this study was to evaluate the response rate, time to progression, and survival of patients with metastatic melanoma treated by direct intratumoral injection with Allovectin-7 (a plasmid DNA encoding the genes HLA-B7 and beta2-microglobulin complexed with a cationic lipid mixture, DMRIE/DOPE. "
08/15/1999 - "Direct intratumoral injection of 100 microg of a IFN-omega pDNA DMRIE/DOPE complex (1:1 DNA:DMRIE mass ratio) for 6 consecutive days resulted in a significant reduction in the tumor volume of NIH: OVCAR-3 ovarian carcinoma or A375 melanoma (P = 0.02). "
09/15/2000 - "UM449 human melanoma tumors in SCID mice received intratumoral injections of DMRIE/DOPE admixed with VR1103, a DNA plasmid encoding the gene for human IL-2. "
10/01/1999 - "We have completed a phase I study, followed by three phase I/II studies, in patients with metastatic melanoma, renal cell carcinoma (RCC), and sarcoma in order to evaluate the safety, toxicity, and antitumor activity of Leuvectin (Vical Inc, San Diego, CA), a gene transfer product containing a plasmid encoding human interleukin (IL)-2 formulated with the cationic lipid 1, 2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE) and administered intratumorally. "
4. Wounds and Injuries (Trauma)
5. Renal Cell Carcinoma (Grawitz Tumor)

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. ammonium bromide
3. Cholesterol
4. Liposomes (Liposome)
5. 1,2- dioleoyloxy- 3- (trimethylammonium)propane
6. Interleukin-2 (IL2)
7. Leuvectin
8. Interleukins
9. Ethanolamine (Colamine)
10. Allovectin-7

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Subcutaneous Injections
3. Injections
4. Immunotherapy
5. Intravesical Administration