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AC 187

a selective amylin antagonist; MW 2890; amino acid sequence given in first source

Also Known As:

AC-187; AC187; acetyl-(Asn30,Tyr32)sCT(8-37); acetyl-(asparagyl(30),tyrosyl(32))sCT(8-37)

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Peptide Fragments: 373
    - AC 187: 5

Experts

1.	Almeida, Lígia Sofia: 1 article (04/2019)
2.	Castro-Lopes, José Manuel: 1 article (04/2019)
3.	Neto, Fani Lourença: 1 article (04/2019)
4.	Potes, Catarina Soares: 1 article (04/2019)
5.	Caramelo, A S: 1 article (11/2016)
6.	Neto, F L: 1 article (11/2016)
7.	Pestana, A C: 1 article (11/2016)
8.	Pontes, M: 1 article (11/2016)
9.	Potes, C S: 1 article (11/2016)
10.	Grabler, Valerie: 1 article (05/2004)

Related Diseases

1.	Body Weight (Weight, Body) 05/01/2004 - "During the 8-day infusion experiment, AC 187 had no clear effect on body weight gain in either group. " 11/01/2001 - "Although body weight was not significantly affected, body fat was increased by about 30% in the AC187 rats, with no difference in lean tissue between the groups. "
2.	Pain (Aches) 11/01/2016 - "L4-5 intrathecal injection of amylin or AC187 showed that both ligands attenuated tonic pain, but blockade of the amylin-receptor action by AC187 decreased further the number of paw jerks in this period. "
3.	Neuroblastoma 07/01/1995 - "Order of potency at inhibiting amylin binding (AC187 > sCT(8-32) > CGRP(8-37)) differed from the order of potency at inhibiting [125I]CGRP binding to SK-N-MC neuroblastoma cells (CGRP(8-37) > AC187 > sCT(8-32)) . "
4.	Hyperalgesia 04/01/2019 - "Acute intrathecal administration of amylin attenuated mechanical hyperalgesia, whereas AC187 reduced mechanical allodynia, suggesting distinct roles of endogenous amylin and of pharmacological amylin doses when targeting spinal cord amylin receptors. "

Related Drugs and Biologics

1.	Islet Amyloid Polypeptide
2.	Islet Amyloid Polypeptide Receptors
3.	Ligands
4.	calcitonin gene-related peptide (8-37)

Related Therapies and Procedures

1.	Spinal Injections