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2- succinyl- 6- hydroxycyclohexa- 2,4- diene- 1- carboxylic acid

an intermediate in the biosynthesis of 2-succinylbenzoic acid; structure in first source

Also Known As:

SHCHC

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid: 2
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Succinates: 13
        2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid: 2

Experts

1.	Gerlt, John A: 2 articles (01/2004 - 12/2003)
2.	Rayment, Ivan: 2 articles (01/2004 - 12/2003)
3.	Taylor Ringia, Erika A: 2 articles (01/2004 - 12/2003)
4.	Garrett, James B: 1 article (01/2004)
5.	Holden, Hazel M: 1 article (01/2004)
6.	Thoden, James B: 1 article (01/2004)
7.	Klenchin, Vadim A: 1 article (12/2003)

Related Diseases

1.

Dehydration (Water Stress)

12/16/2003 - "This establishes the absolute configuration of SHCHC: the C1-carboxylate and the C6-OH leaving group are in a trans orientation, requiring that the dehydration proceed via a syn stereochemical course. "
12/16/2003 - "The epsilon-ammonium group of Lys 235 forms a cation-pi interaction with the cyclohexadienyl moiety of SHCHC, suggesting that Lys 235 also stabilizes the enediolate anion intermediate in the syn dehydration via a similar interaction."
01/13/2004 - "o-Succinylbenzoate synthase (OSBS) from Amycolatopsis, a member of the enolase superfamily, catalyzes the Mn2+-dependent exergonic dehydration of 2-succinyl-6R-hydroxy-2,4-cyclohexadiene-1R-carboxylate (SHCHC) to 4-(2'-carboxylphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB) in the menaquinone biosynthetic pathway. "
12/16/2003 - "o-Succinylbenzoate synthase (OSBS) from Escherichia coli, a member of the enolase superfamily, catalyzes an exergonic dehydration reaction in the menaquinone biosynthetic pathway in which 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) is converted to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB). "

Related Drugs and Biologics

1.	Vitamin K 2 (Vitamin K2)
2.	Phosphopyruvate Hydratase (Enolase)
3.	o-succinylbenzoic acid synthase
4.	o-succinylbenzoic acid
5.	Ammonium Compounds
6.	Cations
7.	Anions