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glutathione-independent formaldehyde dehydrogenase (formaldehyde dehydrogenase)

a zinc-containing metalloenzyme that catalyzes the NAD+-dependent oxidation of long-chain alcohols; GenBank D21201
Also Known As:
formaldehyde dehydrogenase; formaldehyde dehydrogenase, glutathione-independent; GSNOR enzyme; S-nitrosoglutathione reductase; alcohol dehydrogenase 5
Networked: 55 relevant articles (5 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Stamler, Jonathan S: 6 articles (01/2019 - 04/2009)
2. Hare, Joshua M: 5 articles (01/2022 - 04/2009)
3. Rosenthal, Gary J: 4 articles (01/2014 - 05/2011)
4. Balkan, Wayne: 3 articles (01/2022 - 04/2015)
5. Kulandavelu, Shathiyah: 3 articles (01/2022 - 07/2015)
6. Filomeni, Giuseppe: 3 articles (01/2020 - 01/2015)
7. Rizza, Salvatore: 3 articles (01/2020 - 01/2015)
8. Ichinose, Fumito: 3 articles (01/2019 - 04/2013)
9. Blonder, Joan P: 3 articles (01/2014 - 05/2011)
10. Mutka, Sarah C: 3 articles (01/2014 - 05/2011)

Related Diseases

1. Heart Arrest (Cardiac Arrest)
2. Asthma (Bronchial Asthma)
3. Cerebral Malaria
4. Cognitive Dysfunction
5. Neoplasms (Cancer)
01/01/2023 - "Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer."
01/01/2023 - "S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme that has been suggested to play a tumor suppressor role, although the mechanisms responsible are still largely unclear. "
01/01/2023 - "Here we show that S-nitrosoglutathione reductase (GSNOR), the enzyme that deactivates S-nitrosylation, is hypo-expressed in several human malignancies. "
01/01/2016 - "Similarly, although less explored, defects and deficiency in the denitrosylating enzyme S-nitrosoglutathione reductase (GSNOR) have been associated with the development and malignancy of liver and breast cancers, suggesting a primary role for NO signaling-that is, S-nitrosylation, being deeply involved in neoplastic transformation and progression. "
09/12/2023 - "ACOX1: acyl-CoA oxidase 1; ADH5: alcohol dehydrogenase 5 (class III), chi polypeptide; ADIPOQ: adiponectin, C1Q and collagen domain containing; ATG: autophagy related; BECN1: beclin 1; CRTC2: CREB regulated transcription coactivator 2; ER: endoplasmic reticulum; F2RL1: F2R like trypsin receptor 1; FA: fatty acid; FOXO1: forkhead box O1; GLP1R: glucagon like peptide 1 receptor; GRK2: G protein-coupled receptor kinase 2; GTPase: guanosine triphosphatase; HFD: high-fat diet; HSCs: hepatic stellate cells; HTRA2: HtrA serine peptidase 2; IRGM: immunity related GTPase M; KD: knockdown; KDM6B: lysine demethylase 6B; KO: knockout; LAMP2: lysosomal associated membrane protein 2; LAP: LC3-associated phagocytosis; LDs: lipid droplets; Li KO: liver-specific knockout; LSECs: liver sinusoidal endothelial cells; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K5: mitogen-activated protein kinase kinase kinase 5; MED1: mediator complex subunit 1; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin complex 1; NAFLD: non-alcoholic fatty liver disease; NASH: non-alcoholic steatohepatitis; NFE2L2: NFE2 like bZIP transcription factor 2; NOS3: nitric oxide synthase 3; NR1H3: nuclear receptor subfamily 1 group H member 3; OA: oleic acid; OE: overexpression; OSBPL8: oxysterol binding protein like 8; PA: palmitic acid; RUBCNL: rubicon like autophagy enhancer; PLIN2: perilipin 2; PLIN3: perilipin 3; PPARA: peroxisome proliferator activated receptor alpha; PRKAA2/AMPK: protein kinase AMP-activated catalytic subunit alpha 2; RAB: member RAS oncogene family; RPTOR: regulatory associated protein of MTOR complex 1; SCD: stearoyl-CoA desaturase; SIRT1: sirtuin 1; SIRT3: sirtuin 3; SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; SQSTM1/p62: sequestosome 1; SREBF1: sterol regulatory element binding transcription factor 1;SREBF2: sterol regulatory element binding transcription factor 2; STING1: stimulator of interferon response cGAMP interactor 1; STX17: syntaxin 17; TAGs: triacylglycerols; TFEB: transcription factor EB; TP53/p53: tumor protein p53; ULK1: unc-51 like autophagy activating kinase 1; VMP1: vacuole membrane protein 1."

Related Drugs and Biologics

1. Enzymes
2. Protein S
3. Free Radicals
4. Proteins (Proteins, Gene)
5. N6022
6. S-Nitrosothiols
7. Protein Kinases (Protein Kinase)
8. Phosphotransferases (Kinase)
9. Nitric Oxide (Nitrogen Monoxide)
10. Glutathione (Reduced Glutathione)

Related Therapies and Procedures

1. Resuscitation
2. Cardiopulmonary Resuscitation (CPR)
3. Ligation