|1.||Zimmermann, Martin: 1 article (01/2009)|
|2.||Dworeck, Tamara: 1 article (01/2009)|
|3.||Wolf, Klaus: 1 article (01/2009)|
|4.||Zheng, Lin: 1 article (07/2008)|
|5.||Jin, Yi: 1 article (07/2008)|
|6.||Zhang, Kai: 1 article (07/2008)|
|7.||Chen, Yufan: 1 article (07/2008)|
|8.||Chow, Pierce: 1 article (07/2008)|
|9.||Ong, Laichun: 1 article (07/2008)|
|10.||Goh, Kenneth: 1 article (07/2008)|
11/18/1994 - "The present study provides evidence that the GS-X pump is functionally overexpressed in cisplatin-resistant human promyelocytic leukemia HL-60 (HL-60/R-CP) cells, in which the cellular GSH level was substantially enhanced. "
11/18/1994 - "GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation."
06/21/1996 - "Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells."
01/01/1996 - "We provide evidence that the expression of the human MRP/GS-X pump encoded by the MRP (multidrug resistance associated protein) gene is induced by cisplatin in human leukemia HL-60/R-CP (cisplatin-resistant) cells and modulates cell growth inhibition by delta(7)-prostaglandin A1 (PGA1) methyl ester. "
06/21/1996 - "We recently reported that GS-X pump activity, as assessed by ATP-dependent transport of the glutathione-platinum complex and leukotriene C4, and intracellular glutathione (GSH) levels were remarkably enhanced in cis-diamminedichloroplatinum(II) (cisplatin)-resistant human leukemia HL-60 cells (Ishikawa, T., Wright, C. "
|2.||Colonic Neoplasms (Colon Cancer)
04/01/1999 - "Overall, a clear difference in substrate specificity among GS-X pump family members expressed on resistant tumor cells was demonstrated."
12/15/1998 - "The GS-X pump is suggested to play a pivotal role in modulating the biological action of the anti-cancer PG."
09/01/1998 - "Different cancer cell lines exhibited characteristically different GS-X pump activity. "
09/01/1998 - "These results support the proposition that the accumulation of CP-PGs and the immunosuppression of tumor-bearing subjects may be attributed to a lack of GS-X pump activity/expression in lymphocytes."
01/01/2006 - "Clinical approaches for overexpressing MRP1/GS-X pump in lymphocytes could then play a role as a tool for the management of cancer therapeutics."
|4.||Colorectal Neoplasms (Colorectal Cancer)
08/15/1996 - "Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers."
11/01/2000 - "Treatment of human colorectal cancer cells HT29 with interleukin 1beta (IL-1beta) induces expression of the multidrug resistance protein (MRP1) gene encoding the ATP-dependent glutathione S-conjugate export (GS-X) pump and the gamma-glutamylcysteine synthetase (gamma-GCSh) gene encoding heavy (catalytic) subunit of gamma-glutamylcysteine synthetase, the rate-limiting enzyme for the biosynthesis of glutathione (GSH). "
12/01/1997 - "Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells."
10/09/1997 - "Posttranscriptional regulation of MRP/GS-X pump and gamma-glutamylcysteine synthetase expression by 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea and by cycloheximide in human glioma cells."
|1.||Glutathione (Reduced Glutathione)
|5.||Multidrug Resistance-Associated Proteins
|6.||Adenosine Triphosphate (ATP)
|7.||Adenosine Triphosphatases (ATPase)
|10.||Amino Acid Transport System X-AG (Glutamate Transporter)