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GMM2

a nonendocrine ACTH(1-14)-related neuropeptide; minimizes cardiovascular damage in an animal model of moderate brain injury

Also Known As:

GMM(2)

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - GMM2: 3
- Peptides: 82426
  - Neuropeptides: 6772
    - GMM2: 3

Experts

1.	Lee, Ae-Ri Cho: 1 article (11/2005)

Related Diseases

1.	Wounds and Injuries (Trauma) 06/01/1993 - "In view of its potency, low toxicity, and other neuroprotective properties, in both rats and human beings, these data suggest that GMM2 may have considerable clinical benefits in the treatment of central nervous system trauma." 11/01/2005 - "The breaking strength (944.1 +/- 35.6 vs. 411.5 +/- 57.0 Fmax, gmm(-2)) and skin resilience (11.3 +/- 1.4 vs. 6.5 +/- 0.6 mJ/mm2) were significantly increased with EGF-treated wounds as compared with open wounds, suggesting that EGF enhanced the dermal matrix formation and improved the wound mechanical strength. "
2.	Craniocerebral Trauma (Head Injury) 06/01/1993 - "Post-traumatic administration of GMM2, in nanomolar amounts, can prevent or reverse significantly the serious cerebrovascular sequelae of moderate head injury in this animal model. " 01/01/1993 - "These findings complement previously described observations that GMM2 treatment prevents dangerous elevations of ICP (> 25 mm Hg) at 24 to 72 h in this model of head injury. "
3.	Closed Head Injuries 01/01/1993 - "An ACTH1-14-related analog (GMM2) was tested for efficacy in reducing the cerebrovascular pathology that follows moderate, closed-head injury in our rat model. "
4.	Brain Concussion (Cerebral Concussion) 06/01/1993 - "To investigate the effects of a vasoactive analog of adrenocorticotrophic hormone (GMM2) on time-dependent disturbances in regional cerebral blood flow, permeability-capillary surface area products, and intracranial pressure in a rat model of moderate concussion/brain injury. "
5.	Traumatic Brain Injuries (Traumatic Brain Injury) 01/01/1993 - "In view of the potency and low toxicity of GMM2 these observation suggest that the peptide may have considerable clinical application in interrupting pathologic sequelae of traumatic brain injury."

Related Drugs and Biologics

1.	Epidermal Growth Factor (EGF)
2.	Peptides (Polypeptides)
3.	Complement System Proteins (Complement)
4.	Adrenocorticotropic Hormone (ACTH)