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Ro 43-8857
a glycoprotein IIb/IIIa antagonist; structure in first source
Also Known As:
(((4-(4-amidino-N-methylbenzamido)acetyl)-1,2-phenylene)dioxy)diacetic acid; Ro-43-8857
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Benzamides: 115
Ro 43-8857: 2
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzoates: 426
Benzamides: 115
Ro 43-8857: 2
Carboxylic Acids: 973
Acyclic Acids
Acetates: 4994
Ro 43-8857: 2
Carbocyclic Acids
Benzoates: 426
Benzamides: 115
Ro 43-8857: 2
Lipids: 114793
Fatty Acids: 27405
Volatile Fatty Acids: 3052
Acetates: 4994
Ro 43-8857: 2
Related Diseases
1.
Thrombosis (Thrombus)
11/01/1995 - "
Inhibition of arterial thrombus formation in two canine models: comparison of ancrod, a fibrinogen-depleting agent, the thrombin-inhibitor r-hirudin, and the glycoprotein 11b/IIIa-receptor antagonist Ro 43-8857.
"
11/01/1995 - "
Inhibition of arterial thrombus formation by ancrod, a fibrinogen depleting agent isolated from a snake venom, r-hirudin, an inhibitor of thrombin-mediated fibrinogen cleavage, or the glycoprotein (GP)IIB/IIIa-receptor antagonist Ro 43-8857 interfering with fibrinogen binding to platelets, was evaluated in two canine models.
"
2.
Hemorrhage
11/15/1993 - "
However, the ability of Ro 43-8857 to discriminate between anti-aggregatory and bleeding effects was not evident when the bleeding time measurements were performed on the dog jowl.
"
11/15/1993 - "
The effects of two synthetic glycoprotein IIb/IIIa antagonists, Ro 43-8857 and L-700,462, on platelet aggregation and bleeding in guinea-pigs and dogs: evidence that Ro 43-8857 is orally active.
"
Related Drugs and Biologics
1.
Glycoproteins (Glycoprotein)
2.
Platelet Membrane Glycoprotein IIb
3.
Thrombin
4.
Snake Venoms (Snake Venom)
5.
Hirudins
6.
Fibrinogen (Factor I)
7.
Ancrod (Arvin)
8.
Tirofiban (Aggrastat)