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Ro 43-8857

a glycoprotein IIb/IIIa antagonist; structure in first source

Also Known As:

(((4-(4-amidino-N-methylbenzamido)acetyl)-1,2-phenylene)dioxy)diacetic acid; Ro-43-8857

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Thrombosis (Thrombus) 11/01/1995 - "Inhibition of arterial thrombus formation in two canine models: comparison of ancrod, a fibrinogen-depleting agent, the thrombin-inhibitor r-hirudin, and the glycoprotein 11b/IIIa-receptor antagonist Ro 43-8857." 11/01/1995 - "Inhibition of arterial thrombus formation by ancrod, a fibrinogen depleting agent isolated from a snake venom, r-hirudin, an inhibitor of thrombin-mediated fibrinogen cleavage, or the glycoprotein (GP)IIB/IIIa-receptor antagonist Ro 43-8857 interfering with fibrinogen binding to platelets, was evaluated in two canine models. "
2.	Hemorrhage 11/15/1993 - "However, the ability of Ro 43-8857 to discriminate between anti-aggregatory and bleeding effects was not evident when the bleeding time measurements were performed on the dog jowl. " 11/15/1993 - "The effects of two synthetic glycoprotein IIb/IIIa antagonists, Ro 43-8857 and L-700,462, on platelet aggregation and bleeding in guinea-pigs and dogs: evidence that Ro 43-8857 is orally active."

Related Drugs and Biologics

1.	Glycoproteins (Glycoprotein)
2.	Platelet Membrane Glycoprotein IIb
3.	Thrombin
4.	Snake Venoms (Snake Venom)
5.	Hirudins
6.	Fibrinogen (Factor I)
7.	Ancrod (Arvin)
8.	Tirofiban (Aggrastat)