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8- amino- 1,3- bis(cyclopropylmethyl)xanthine
a selective type IV phosphodiesterase inhibitor; structure given in first source
Also Known As:
BRL 61063; BRL-61063; BRL61063; 1H-Purine-2,6-dione, 8-amino-1,3-bis(cyclopropylmethyl)-3,7-dihydro-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Xanthines: 123
8-amino-1,3-bis(cyclopropylmethyl)xanthine: 3
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purinones: 2
Xanthines: 123
8-amino-1,3-bis(cyclopropylmethyl)xanthine: 3
Related Diseases
1.
Intracranial Vasospasm
02/01/1997 - "
In contrast, prolonged treatment with BRL 61063 failed to alter the development of basilar spasm in the two hemorrhage canine models of chronic cerebral vasospasm.
"
2.
Spasm (Spasms)
02/01/1997 - "
In contrast, prolonged treatment with BRL 61063 failed to alter the development of basilar spasm in the two hemorrhage canine models of chronic cerebral vasospasm.
"
3.
Septic Shock (Toxic Shock Syndrome)
12/01/1994 - "
Beneficial effects of the phosphodiesterase inhibitors BRL 61063, pentoxifylline, and rolipram in a murine model of endotoxin shock.
"
4.
Infections
01/06/1995 - "
Treatment with either BRL 61063 or pentoxifylline had little or no effect on the Poly I:C-induced candidacidal activity of BAL cells indicating that these compounds are unlikely to compromise non-specific host defense against infection.
"
5.
Hemorrhage
02/01/1997 - "
In contrast, prolonged treatment with BRL 61063 failed to alter the development of basilar spasm in the two hemorrhage canine models of chronic cerebral vasospasm.
"
Related Drugs and Biologics
1.
Pentoxifylline (Trental)
2.
Rolipram
3.
Poly I-C
4.
Phosphodiesterase Inhibitors