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WIN 51708

neurokinin-1 receptor antagonist

Also Known As:

17-hydroxy-17-ethynyl-5alpha-androstano(3,2-b)pyrimido(1,2-a)benzimidazole; WIN-51708

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Androstanes: 11
      - WIN 51708: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - WIN 51708: 3

Experts

1.	Ito, Hiromoto: 2 articles (01/2012 - 10/2011)
2.	Sakai, Atsushi: 2 articles (01/2012 - 10/2011)
3.	Suzuki, Hidenori: 2 articles (01/2012 - 10/2011)
4.	Makino, Akira: 1 article (01/2012)
5.	Uematsu, Takuya: 1 article (10/2011)
6.	Goodchild, Ann K: 1 article (06/2005)
7.	Makeham, John M: 1 article (06/2005)
8.	Pilowsky, Paul M: 1 article (06/2005)

Related Diseases

1.	Hyperalgesia 01/01/2012 - "Systemic injection of an NK1 receptor antagonist, WIN 51708, significantly inhibited the joint swelling, but not the mechanical allodynia, on day 7 in CAIA mice. " 10/01/2011 - "Administration of the tachykinin NK(1) receptor antagonist WIN 51708 or GR 82334 into the affected ankle joint at day 3 following intra-articular CFA injection reduced the mechanical hyperalgesia 12 h after the tachykinin NK(1) receptor antagonist injection and their analgesic effects persisted for at least 2 days. "
2.	Hypoxia (Hypoxemia) 06/01/2005 - "NK1 receptor antagonism in the RVLM, with WIN 51708 significantly attenuated the sympathoexcitatory response to hypoxia but had no effect on baseline respiratory function. "

Related Drugs and Biologics

1.	Neurokinin-1 Receptors (Neurokinin 1 Receptor)
2.	Tachykinins
3.	Analgesics (Analgesic Drugs)
4.	GR 82334