glutapyrone

a Latvian compound; exhibits significant antiepileptic effects; lacks calcium antagonistic properties characteristic of 1,4-dihydropyridine compounds

Also Known As:

2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridyl-4-carboxamido)glutaric acid disodium salt; glutapiron

Networked: 8 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Dihydropyridines: 214
      - glutapyrone: 8
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Acidic Amino Acids: 44
    - Glutamates: 45
      - glutapyrone: 8
  - Dicarboxylic Amino Acids: 20
    - Glutamates: 45
      - glutapyrone: 8

Experts

1.	Duburs, Gunars: 1 article (11/2008)
2.	Dzirkale, Zane: 1 article (11/2008)
3.	Gordjushina, Valentina: 1 article (11/2008)
4.	Isajevs, Sergejs: 1 article (11/2008)
5.	Klusa, Vija: 1 article (11/2008)
6.	Kratovska, Aina: 1 article (11/2008)
7.	Pilipenko, Jelena: 1 article (11/2008)
8.	Pupure, Jolanta: 1 article (11/2008)
9.	Rumaks, Juris: 1 article (11/2008)
10.	Svirskis, Simons: 1 article (11/2008)

Related Diseases

1.	Seizures (Absence Seizure) 10/01/1993 - "As previously shown, that glutapyrone has an influence on 45Ca2+ uptake by rat cortical synaptosomes (evoked by K+ depolarization) as compared with nifedipine and nimodipine, and it was effective in pentylenetetrazol-induced seizures in rats and mice. " 10/01/1993 - "The experiments on focal penicillin-induced epileptic activity in the brain cortex (Wistar rats) and bicuculline- and thiosemicarbazide-induced seizures (Icr:Icl mice) showed that the glutapyrone possessed a significant antiepileptic activity. " 09/01/1993 - "Experiments on male Wistar rats and Icr:Icl mice studied the influence of the novel compound--amino acid-containing 1,4-dihydropyridine derivative glutapyrone (G) on acute generalized seizures, arecoline and nicotine tremor, and 45Ca2+ uptake in brain synaptosomes. "
2.	Cardiotoxicity 11/01/2008 - "This study demonstrates the effective protection by compounds of atypical 1,4-dihydropyridine (DHP) series cerebrocrast, glutapyrone and tauropyrone against neuro- and cardiotoxicity caused by the model compound azidothymidine, a well-known mitochondria-compromising anti-HIV drug. "
3.	Mitochondrial Myopathies (Mitochondrial Myopathy) 09/01/1997 - "The results suggest the usefulness of further study of cerebrocrast and glutapyrone in preventing AZT-induced and some other mitochondrial myopathies."
4.	Tremor (Tremors) 09/01/1993 - "Experiments on male Wistar rats and Icr:Icl mice studied the influence of the novel compound--amino acid-containing 1,4-dihydropyridine derivative glutapyrone (G) on acute generalized seizures, arecoline and nicotine tremor, and 45Ca2+ uptake in brain synaptosomes. "
5.	Pain (Aches) 04/01/2002 - "Glutapyrone belonging to a new type of amino acid-containing 1,4-dihydropyridines produced a protective effect on periodontal tissues and gastric mucosa in rats with different resistance to stress during acute emotional and pain stress."

Related Drugs and Biologics

1.	Pentylenetetrazole (Metrazol)
2.	Nimodipine (Modus)
3.	Nifedipine (Adalat)
4.	2,6- dimethyl- 3,5- bis(2'- propoxyethoxycarbonyl)- 4- (2''- difluoromethoxyphenyl)- 1,4- dihydropyridine
5.	1,4-dihydropyridine (dihydropyridine)
6.	Anti-HIV Agents (AIDS Drugs)
7.	Zidovudine (Retrovir)
8.	tauropyrone
9.	Amino Acids
10.	Drinking Water