|1.||Kataoka, Hiroaki: 4 articles (03/2010 - 02/2006)|
|2.||List, Karin: 2 articles (01/2015 - 01/2012)|
|3.||Zoratti, Gina L: 2 articles (01/2015 - 01/2012)|
|4.||Fabre, Aurélie: 2 articles (03/2010 - 07/2006)|
|5.||Marchand-Adam, Sylvain: 2 articles (03/2010 - 07/2006)|
|6.||Soler, Paul: 2 articles (03/2010 - 07/2006)|
|7.||Crestani, Bruno: 2 articles (03/2010 - 07/2006)|
|8.||Fukushima, Tsuyoshi: 2 articles (03/2008 - 02/2006)|
|9.||Okumura, Tadayoshi: 2 articles (01/2006 - 07/2002)|
|10.||Kaibori, Masaki: 2 articles (01/2006 - 07/2002)|
07/01/2002 - "Production of proHGF in the liver increased in the following order: rats with normal liver, rats with fibrosis, and rats with cirrhosis. "
07/01/2002 - "We hypothesized that impairment of liver regeneration in cirrhosis is in part because of the absence of activation of proHGF to mature HGF. "
07/01/2002 - "These results demonstrate that the conversion of proHGF into mature HGF is impaired after liver resection in liver cirrhosis, while proHGF production is similar in the livers of normal, fibrosis, and cirrhosis groups. "
01/01/2006 - "Studies were performed to examine whether the exogenous administration of recombinant human (rh) HGF-activator converts proHGF to biologically active (mature) HGF, inducing an enhancement of liver regeneration in cirrhosis. "
03/01/2010 - "Imbalance in the pro-hepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice."
|2.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
04/28/2011 - "In this study, we show that the oncogenic protease matriptase is ubiquitously co-expressed with the c-Met in human squamous cell carcinomas and amplifies migratory and proliferative responses of primary epithelial cells to the cognate ligand for c-Met, pro-hepatocyte growth factor/scatter factor (proHGF/SF), through c-Met and Gab1 signaling. "
03/01/2008 - "These data suggest that KLK4 and KLK5 mediate HGFA-induced activation of pro-HGF/SF within tumor tissue, which may thereafter trigger a series of events leading to tumor progression via the MET receptor."
10/01/2007 - "In cancer cells, the regulation of this pathway has been shown to be disrupted, allowing an increase in activation of pro-HGF to active HGF. "
10/01/2001 - "Hepatocyte growth factor/scatter factor (HGF/SF), a cytokine associated with cancer cell migration and invasion, is synthesised as pro-HGF/SF and requires activation by factors such as the HGF activator (HGFA). "
07/13/2006 - "Matriptase is an epithelium-derived type II transmembrane serine protease and has been implicated in the activation of substrates such as pro-HGF/SF and pro-uPA, which are likely involved in tumor progression and metastasis. "
03/01/2010 - "These observations demonstrate that, in contrast with the uPA/uPAR system, the TTSPs matriptase and hepsin are direct pericellular activators of pro-HGF, and that together these proteins may form a pathway contributing to their involvement in pathological situations, including cancer."
01/01/2015 - "Similarly, inhibition of matriptase catalytic activity using a selective small-molecule inhibitor abrogates the activation of c-Met, Gab1 and AKT, in response to pro-HGF, which functionally leads to attenuated proliferation in breast carcinoma cells. "
03/01/2010 - "Activation of pro-HGF by PC3 prostate carcinoma cells was abolished by both protease inhibition and matriptase-targeting siRNA (small interfering RNA), and scattering of MDCK (Madin-Darby canine kidney) cells in the presence of pro-HGF was abolished by inhibition of matriptase. "
|5.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "Here we demonstrate by genetic deletion and silencing that the proliferation impairment in matriptase-deficient breast cancer cells is caused by their inability to initiate activation of the c-Met signalling pathway in response to fibroblast-secreted pro-HGF. "
01/01/2012 - "To determine whether the proteases required to activate pro-HGF were present in the breast cancer cells, we utilized a fibroblast cell line expressing pro-HGF (RMF-HGF). "
|1.||pro-hepatocyte growth factor
|2.||Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
|6.||Serine Proteases (Serine Protease)
|7.||Proteins (Proteins, Gene)
|8.||Peptide Hydrolases (Proteases)
|9.||Small Interfering RNA (siRNA)