2- butyl- 3- ((2'- (1H- tetrazol- 5- yl)biphenyl- 4- yl)methyl)- 3H- imidazo(4,5- b)pyridine

an angiotensin II-receptor antagonist; structure in first source

Also Known As:

3H-imidazo(4,5-b)pyridine, 2-butyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, sodium salt; FK 739; FK-739

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

1.	Hypertension (High Blood Pressure) 11/01/1993 - "These results indicate that FK 739 is a potent and competitive antagonist for AT1-type receptors, and suggest that FK 739 might be a safe and useful agent for the treatment of hypertension in clinical trials." 09/01/2004 - "To clarify the precise mechanisms involved in the reduced coronary flow reserve in hypertension, we compared the effects of the angiotensin II type 1 (AT1) receptor antagonist FK-739 with those of the angiotensin-converting enzyme (ACE) inhibitor enalapril for 6 weeks on the smooth muscle (SM) cell phenotype in intramyocardial arteries from male Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). "
2.	Vascular Remodeling 09/01/2004 - "Although both drugs showed little effect on the vascular remodeling of the intramyocardial arteries in the SHR hearts, FK-739, but not enalapril, significantly restored SM2 and GATA-6 in the SHR hearts to the same levels as those of the vehicle WKY group. "
3.	Hypertrophy 01/01/1996 - "Both FK-739 and enalapril induced a significant decrease in blood pressure (p < 0.001) and regression of LV hypertrophy (p < 0.001) compared with vehicle, with no differences between the treated groups. "
4.	Edema (Dropsy) 11/01/1993 - "Oral administration of FK 739 (10 and 32 mg/kg) did not affect the capsaicin-induced bronchial edema. "
5.	Cough 11/01/1993 - "Additionally, we studied whether FK 739 would cause side effects such as dry cough, like other ACE inhibitors did. "

1.	Enalapril
2.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
3.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
4.	Capsaicin (Zostrix)
5.	Angiotensin II

1.	Oral Administration