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lactocepin

encodes a subtilisin-like cell envelope proteinase of Lactococcus lactis; amino acid sequence has been determined

Also Known As:

SK11 cell envelope proteinase

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        lactocepin: 2
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        lactocepin: 2

Experts

1.	Haller, Dirk: 2 articles (03/2013 - 04/2012)
2.	Hörmannsperger, Gabriele: 2 articles (03/2013 - 04/2012)
3.	von Schillde, Marie-Anne: 2 articles (03/2013 - 04/2012)
4.	Alpert, Carl-Alfred: 1 article (04/2012)
5.	Bäuerl, Christine: 1 article (04/2012)
6.	Hahne, Hannes: 1 article (04/2012)
7.	Hrncir, Tomas: 1 article (04/2012)
8.	Kuster, Bernhard: 1 article (04/2012)
9.	Pérez-Martínez, Gaspar: 1 article (04/2012)
10.	Steidler, Lothar: 1 article (04/2012)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 03/01/2013 - "As immune cell recruitment is a major proinflammatory mechanism our findings suggest that lactocepin might be of broad therapeutic relevance in an array of inflammatory diseases like IBD, allergic skin inflammation and psoriasis."
2.	Inflammation (Inflammations) 03/01/2013 - "As immune cell recruitment is a major proinflammatory mechanism our findings suggest that lactocepin might be of broad therapeutic relevance in an array of inflammatory diseases like IBD, allergic skin inflammation and psoriasis." 03/01/2013 - "We found Lactobacillus casei/paracasei-produced lactocepin to selectively degrade pro-inflammatory chemokines, resulting in reduced immune cell infiltration and reduced inflammation in experimental IBD models. "
3.	Ileitis 04/19/2012 - "We identified Lactobacillus paracasei prtP-encoded lactocepin as a protease that selectively degrades secreted, cell-associated, and tissue-distributed IP-10, resulting in significantly reduced lymphocyte recruitment after intraperitoneal injection in an ileitis model. "

Related Drugs and Biologics

1.	Chemokines
2.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Intraperitoneal Injections