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integrin alpha7

expression is used as a marker for early stages of myogenesis; has 3 isoforms alpha7 A, B, & C; amino acid sequence has been determined
Also Known As:
CD49g antigen; ITGA7 protein, human; Itga7 protein, mouse; Itga7 protein, rat; alpha(7) integrin; alpha(7)-integrin; integrin alpha 7, mouse; integrin alpha 7, rat; integrin, alpha 7, human
Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kaufman, Stephen J: 3 articles (02/2008 - 07/2004)
2. Yu, Yan P: 2 articles (09/2010 - 06/2007)
3. Luo, Jian-Hua: 2 articles (09/2010 - 06/2007)
4. Nelson, Joel: 2 articles (09/2010 - 06/2007)
5. Chao, Jun-Tzu: 2 articles (04/2006 - 07/2004)
6. Wilson, Emily: 2 articles (04/2006 - 07/2004)
7. Meininger, Gerald A: 2 articles (04/2006 - 07/2004)
8. Ramos, Kenneth S: 2 articles (04/2006 - 07/2004)
9. Mayer, Ulrike: 2 articles (03/2006 - 08/2004)
10. Pai, Man-Hui: 1 article (01/2011)

Related Diseases

1. Prostatic Neoplasms (Prostate Cancer)
06/06/2007 - "Integrin alpha7 mutations were associated with increased recurrence of human prostate cancer (nine recurrences among 13 patients with integrin alpha7 mutations versus one among eight without such mutations; odds ratio [OR] = 14, 95% CI = 1.15 to 782, P = .024) and hepatocellular carcinoma (five recurrences among eight patients with integrin alpha7 mutations versus one among 16 without such mutations, OR = 21, 95% CI = 1.6 to 1245; P = .007). "
06/06/2007 - "Focal or no integrin alpha7 expression in human prostate cancer and soft tissue leiomyosarcoma was associated with a reduction of metastasis-free survival (for example, for prostate cancer with focal or no expression, 5-year metastasis-free survival was 32%, 95% CI = 24.4% to 40.3%, and for prostate cancer with at least weak expression, it was 85%, 95% CI = 79% to 91%; P<.001). "
06/06/2007 - "Forced expression of normal integrin alpha7 in prostate cancer and leiomyosarcoma cell lines suppressed tumor growth and metastasis both in vitro and in vivo. "
06/06/2007 - "Integrin alpha7 mutations that generate truncations were found in specimens of 16 of 28 prostate cancers (57%, 95% confidence interval [CI] = 37% to 76%), five of 24 hepatocellular carcinomas (21%, 95% CI = 7% to 42%), five of six glioblastomas multiforme (83%, 95% CI = 36% to 99%), and one of four leiomyosarcomas (25%, 95% CI = 0.6% to 81%). "
06/06/2007 - "Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma."
2. Liver Neoplasms (Liver Cancer)
3. Leiomyosarcoma
4. Glioblastoma (Glioblastoma Multiforme)
5. Vascular System Injuries

Related Drugs and Biologics

1. integrin alpha7beta1
2. Dystrophin
3. Laminin (Merosin)
4. Caspase 3 (Caspase-3)
5. Myosin Heavy Chains (Myosin Heavy Chain)
6. Complementary DNA (cDNA)
7. Laminin Receptors
8. Proteins (Proteins, Gene)
9. Protein Kinases (Protein Kinase)
10. Naltrexone (ReVia)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)