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192 IgG-saporin

an immunotoxin composed of the monoclonal anti-NGF receptor antibody, 192 IgG linked to saporin; destroys cholinergic neurons in the basal forebrain
Also Known As:
192-saporin
Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Nanobashvili, A: 2 articles (01/2001 - 06/2000)
2. Kokaia, M: 2 articles (01/2001 - 06/2000)
3. Lindvall, O: 2 articles (01/2001 - 06/2000)
4. Leanza, G: 2 articles (01/2001 - 06/2000)
5. Ferencz, I: 2 articles (01/2001 - 06/2000)
6. Winblad, Bengt: 1 article (09/2011)
7. Solas, Maite: 1 article (09/2011)
8. Mateos, Laura: 1 article (09/2011)
9. Cedazo-Mínguez, Angel: 1 article (09/2011)
10. Ramírez, María J: 1 article (09/2011)

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
12/08/1995 - "However, recent data suggest that injection of 192-saporin directly into components of the cholinergic basal forebrain can be used to further elaborate the function of this brain system and to model disorders of cholinergic hypofunction such as Alzheimer's disease."
07/01/1997 - "Although our data does support the use of 192 IgG saporin as a selective cholinergic toxin in the basal forebrain, it further suggests that assessment of spatial learning in the rat following 192 IgG saporin lesions of the basal forebrain in combination with lesions to other neurotransmitter systems, may be a more viable approach to the elucidation of the neuropathological mechanisms that are associated with the cognitive deficits seen in Alzheimer's Disease."
12/01/1996 - "Although our data do support the use of 192 IgG saporin as a selective cholinergic toxin in the basal forebrain, they further suggests that assessment of spatial learning in the rat following 192 IgG saporin lesions of the basal forebrain in combination with lesions to other neurotransmitter systems, may be a more viable approach to the elucidation of the neuropathological mechanisms that are associated with the cognitive deficits seen in Alzheimer's disease."
07/08/1996 - "Site-specific injection of IgG 192-saporin is a useful approach to explore the functions of the cholinergic basal forebrain and to model diseases of cholinergic hypofunction such as Alzheimer's disease."
02/01/1995 - "These results indicate that 192-saporin treated rats can be used to model a key feature of Alzheimer's disease and that anti-neuronal immunotoxins are a powerful approach to selective neural lesioning."
2. Seizures (Seizure)
3. AIDS-Related Complex (ARC)
4. Retrograde Degeneration
5. Pathologic Processes

Related Drugs and Biologics

1. Immunotoxins (Immunotoxin)
2. glycogen synthase kinase 3 beta
3. Brain-Derived Neurotrophic Factor (BDNF)
4. Neurotransmitter Agents (Neurotransmitter)
5. Messenger RNA (mRNA)
6. Nerve Growth Factor (NGF)
7. Immunoglobulin G (IgG)
8. harpin (messenger)

Related Therapies and Procedures

1. Intraventricular Injections
2. Denervation