S 14489

structure given in first source; antagonizes postsynaptic 5-HT(1A) receptors; agonist for 5-HT(1A) autoreceptors

Also Known As:

4-(benzodioxan-5-yl)-1-(2-(benzocyclobutan-1-yl)ethyl)piperazine; S-14489; Piperazine, 1-(2-bicyclo(4.2.0)octa-1,3,5-trien-7-ylethyl)-4-(2,3-dihydro-1,4-benzodioxin-5-yl)-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - S 14489: 1
  - Dioxanes
    - S 14489: 1

Related Diseases

1.	Hypothermia 01/01/1994 - "The spontaneous tail-flicks, flat-body posture and hypothermia mediated by an action of the 5-HT1A agonist 8-OH-DPAT at postsynaptic 5-HT1A receptors were dose-dependently and completely antagonized by S 14489, S 15535 and S15931 at doses of 0.63 to 10.0 and 2.5 to 40.0 mg/kg for s.c. "

Related Drugs and Biologics

1.	Serotonin 5-HT1 Receptor Agonists
2.	S 15931
3.	4- (benzodioxan- 5- yl)- 1- (indan- 2- yl)piperazine
4.	hydroxide ion