|1.||Hino, Motohiro: 1 article (05/2007)|
|2.||Matsuoka, Nobuya: 1 article (05/2007)|
|3.||Moriguchi, Akira: 1 article (05/2007)|
|4.||Maemoto, Takuya: 1 article (05/2007)|
|5.||Nakada, Hirohisa: 1 article (05/2007)|
|6.||Muramatsu, Yuko: 1 article (05/2007)|
|7.||Tojo, Nobuteru: 1 article (05/2007)|
|8.||Furuichi, Yasuhisa: 1 article (05/2007)|
|1.||Transient Ischemic Attack
05/29/2007 - "Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models."
05/29/2007 - "These findings suggest that FR901459 exerts a potent neuroprotective effect by inhibiting mitochondrial damage in vitro, but that in in vivo transient cerebral ischemia, its immunosuppressive component which possibly acts via the inhibition of calcineurin may play a more important role in attenuating brain damage than its inhibitory effect against mitochondrial damage."
|3.||Brain Ischemia (Cerebral Ischemia)
05/29/2007 - "In a transient global cerebral ischemia model in gerbils, FR901459 showed the dose-dependent suppression of neuronal cell death, while FR901459 was less efficacious than CsA. "
05/29/2007 - "Here, we investigated the neuroprotective profile of a novel derivative of CsA, FR901459, by evaluating its effects against in vitro mitochondrial damage and in vivo brain damage in transient global or focal cerebral ischemia models, in comparison with those of CsA. "