|1.||Zhu, Wensi: 1 article (10/2014)|
|2.||Song, Li: 1 article (10/2014)|
|3.||Li, Zhuoyu: 1 article (10/2014)|
|4.||Li, Wenling: 1 article (10/2014)|
|5.||Newton, Ian P: 1 article (10/2014)|
|6.||Jia, Yuxin: 1 article (10/2014)|
|7.||Bergrem, Astrid: 1 article (07/2011)|
|8.||Mowinckel, Marie-Christine: 1 article (07/2011)|
|9.||Sandset, Per Morten: 1 article (07/2011)|
|10.||Jacobsen, Anne Flem: 1 article (07/2011)|
|1.||Activated Protein C Resistance (APC Resistance)
04/01/2002 - "To study this, recombinant FV mutants were reconstituted in FV-deficient plasma, after which normalized APC-sensitivity ratios (n-APC-SRs) were measured in activated partial thromboplastin time-based and Russell's Viper Venom time-based APC-resistance tests. "
03/01/1998 - "Using cutoff points derived from the normal PCR-screened population (n = 162), two assays for APC resistance (APC-SR and n-APC-SR) gave poor concordance with the PCR assay (sensitivity 29% and 57%, respectively). "
01/01/1996 - "Incomplete cosegregation of heterozygosity for the 1691 G-->A mutation with APC resistance (APC-SR < 2.4 or n-APC-SR < 0.75) was observed, showing that the functional assay alone is insufficient for a firm diagnosis. "
05/01/2009 - "In this study, we report an interaction of tumor-associated N-terminal APC fragments (N-APC) with Mad2, an essential mitotic checkpoint protein, providing a direct molecular support for linking APC mutations to the generation of CIN. "
05/01/2009 - "Expressing a tumor-associated N-APC mutant in mammalian cells with an intact mitotic checkpoint produces premature anaphase onset with missegregated chromosomes."
10/01/2014 - "We discovered that expression of tumor-associated N-terminal APC fragments (APC-N, APC-N1, APC-N2, and APC-N3, which contain amino acids 1-1018, 1-448, 449-781, and 782-1018 respectively), resulted in primary cilia defects. "
09/01/1996 - "In a pilot study, 28 consecutive patients with thrombosis and 23 age and sex matched healthy normal controls were investigated with normalised APC sensitivity ratio (n-APC-SR) to know the defect exists and if so its prevalence in India. "
09/01/1998 - " Several of these effects of OCs were more pronounced in former thrombosis patients than in healthy women specifically on factor VII, antithrombin, n-APC-sr, and protein C. "
09/01/1998 - "In the former thrombosis patients several of these effects of oral contraceptives were more pronounced than in healthy women: specifically on factor VII, antithrombin, n-APC-sr and protein C. "
|4.||Venous Thrombosis (Deep-Vein Thrombosis)
07/01/2011 - "Also in carriers of the F5 rs6025 polymorphism the risk for venous thrombosis was increased for women with higher n-aPC-sr. Our findings substantiate the importance of the aPC resistant phenotype as a risk factor for pregnancy-related venous thrombosis."
07/01/2011 - "Pregnant women and women using oral contraceptives and/or anticoagulants were excluded due to the effect on the n-aPC-sr. In women without the F5 rs6025 polymorphism, free tissue factor pathway inhibitor (TFPI), free protein S and protein C activity were associated with n-aPC-sr. Unadjusted odds ratio for venous thrombosis for women with n-aPC-sr in the 4th quartile as compared with n-aPC-sr below the 4th quartile was 2·4 (95% confidence interval 1·7-3·6). "
|5.||Colonic Neoplasms (Colon Cancer)
|4.||Factor VII (Proconvertin)
|7.||lipoprotein-associated coagulation inhibitor (TFPI)