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pteridine reductase

has been sequenced; responsible for methotrexate resistance; isolated from Leishmania sp

Also Known As:

LTDH short chain dehydrogenase; PTR1 pteridine reductase; pteridine reductase 1

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - pteridine reductase: 12

Experts

1.	Pozzi, Cecilia: 2 articles (11/2021 - 12/2017)
2.	Hunter, William N: 2 articles (01/2010 - 07/2009)
3.	Tulloch, Lindsay B: 2 articles (01/2010 - 07/2009)
4.	Amewu, Richard K: 1 article (12/2021)
5.	Bienibuor, Alfred K: 1 article (12/2021)
6.	Devine, Robert N O A: 1 article (12/2021)
7.	Kwofie, Samuel K: 1 article (12/2021)
8.	Miller, Whelton A: 1 article (12/2021)
9.	Sakyi, Patrick O: 1 article (12/2021)
10.	Costi, Maria Paola: 1 article (11/2021)

Related Diseases

1.	Leishmaniasis 01/14/2010 - "Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases." 01/01/2019 - "Targeting pteridine reductase 1 and dihydrofolate reductase: the old is a new trend for leishmaniasis drug discovery." 12/01/2021 - "Numerous studies to understand the biochemistry of leishmaniasis and its pathogenesis have identified druggable targets including ornithine decarboxylase, trypanothione reductase, and pteridine reductase, which are relevant for the survival and growth of the parasites. " 12/01/2019 - "Dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) involved in folate biosynthesis in leishmania have been established as suitable targets for development of chemotherapy against leishmaniasis. "
2.	African Trypanosomiasis (Nagana) 02/01/2014 - "Trypanosoma brucei Pteridine reductase (TbPTR1) is of vital importance and is an established drug target for dreaded Human African trypanosomiasis (HAT). " 01/14/2010 - "Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases." 07/23/2009 - "The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. "
3.	Infections 03/28/2023 - "However, DHFR inhibitors are largely ineffective in controlling trypanosomatid infections, largely due to the presence of Pteridine reductase 1 (PTR1). " 12/15/2006 - "Neither in vitro MTHFR activity nor the growth of mthfr(-) mutants or MTHFR overexpressors were differentially affected by antifolates known to inhibit parasite growth via targets beyond dihydrofolate reductase and pteridine reductase 1. In a mouse model of infection mthfr(-) mutants showed good infectivity and virulence, indicating that sufficient methionine is available within the parasitophorous vacuole to meet the needs of the parasite."
4.	Neglected Diseases 12/06/2017 - "In a continuation of our computational efforts to find new natural inhibitors of a variety of target enzymes from parasites causing neglected tropical diseases (NTDs), we now report on 15 natural products (NPs) that we have identified as inhibitors of Leishmania major pteridine reductase I (LmPTR1) through a combination of in silico and in vitro investigations. "
5.	Parasitic Diseases (Parasitic Disease) 11/30/2021 - "Three open-source anti-kinetoplastid chemical boxes derived from a whole-cell phenotypic screening by GlaxoSmithKline (Tres Cantos Anti-Kinetoplastid Screening, TCAKS) were exploited for the discovery of a novel core structure inspiring new treatments of parasitic diseases targeting the trypansosmatidic pteridine reductase 1 (PTR1) and dihydrofolate reductase (DHFR) enzymes. "

Related Drugs and Biologics

1.	Ornithine Decarboxylase (Decarboxylase, Ornithine)
2.	trypanothione reductase
3.	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)
4.	Enzymes
5.	Neopterin
6.	Thymidylate Synthase
7.	Methionine (L-Methionine)
8.	Folic Acid Antagonists
9.	Folic Acid (Vitamin M)
10.	thymidylate synthase-dihydrofolate reductase

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)