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ciprokiren
a renin inhibitor; prevents neointima formation to the same extent as cilazapril
Also Known As:
Ro 44-9375; Ro-44-9375; 1H-Imidazole-4-propanamide, N-(1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl)-alpha-((2-(((1,1-dimethyl-2-(4-morpholinyl)-2-oxoethyl)sulfonyl)methyl)-1-oxo-3-phenylpropyl)amino)-, (1S-(1R*(R*(R*)),2S*,3R*))-
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
ciprokiren: 2
Related Diseases
1.
Neointima
01/01/1994 - "
Both, ciprokiren and cilazapril prevented neointima formation to the same extent (inhibition by 42 and 49%, respectively, p < 0.05).
"
2.
Vascular System Injuries
01/01/1994 - "
Vascular injury was induced by endothelial denudation of the right carotid artery of guinea pigs treated either by saline (control group), cilazapril (30 mg/kg/day) or ciprokiren (24 mg/kg/day).
"
3.
Heart Failure
06/01/1996 - "
To determine the role of the renin-angiotensin system and the bradykinin pathway in the mechanism of action of angiotensin-converting enzyme inhibitors in heart failure, the acute effects of enalaprilat (1 mg/kg) were compared with those of a renin inhibitor (ciprokiren, 1 mg/kg i.v.) in 10 chronically instrumented conscious dogs with heart failure induced by right ventricular pacing (3 wk, 240 beats/min).
"
Related Drugs and Biologics
1.
Cilazapril
2.
Enalaprilat (Vasotec)
3.
Bradykinin
4.
Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
5.
Renin Inhibitors