|1.||Popescu, Nicholas C: 11 articles (01/2014 - 03/2004)|
|2.||Ng, Irene Oi-Lin: 6 articles (01/2013 - 10/2005)|
|3.||Ko, Frankie Chi Fat: 5 articles (07/2014 - 01/2009)|
|4.||Lo, Su Hao: 4 articles (12/2015 - 01/2008)|
|5.||Olayioye, Monilola A: 4 articles (08/2015 - 01/2009)|
|6.||Chan, Lo-Kong: 4 articles (01/2013 - 01/2009)|
|7.||Yam, Judy Wai Ping: 4 articles (01/2013 - 01/2009)|
|8.||Shih, Yi-Ping: 3 articles (12/2015 - 10/2008)|
|9.||Qian, Xiaolan: 3 articles (12/2014 - 05/2007)|
|10.||Lowy, Douglas R: 3 articles (12/2014 - 05/2007)|
01/01/2013 - "The present study suggests that ARHGAP11A, a cell cycle-dependent RhoGAP, is a critical regulator of cancer cell mobility and is thus a promising therapeutic target in invasive cancers. "
05/01/2008 - "To address the importance of the RhoGAP function of DLC-1 in tumor suppression, we performed biochemical and biological studies evaluating DLC-1 in NSCLC. "
06/01/2003 - "Previous studies from our laboratory have demonstrated that p190-B RhoGAP (p190-B) is differentially expressed in the Cap cells of terminal end buds (TEBs) and poorly differentiated rodent mammary tumors. "
12/01/2015 - "DLC1 is a RhoGAP-containing tumor suppressor and many of DLC1's functions are absolutely dependent on its RhoGAP activity. "
11/01/2014 - "ROCK inhibition or downregulation of p190A RhoGAP expression reduces entosis and increases the transformed growth of epithelial cadherin-expressing tumor cells. "
|2.||Oculocerebrorenal Syndrome (Lowe Syndrome)
09/01/2006 - "The objective of our study was to further characterize the ocrl1 RhoGAP-homology domain by analyzing the effect of two missense mutations in this domain, I751N and A780P, which were previously reported in Lowe syndrome patients. "
09/01/2010 - "Lowe syndrome (LS) is a rare X-linked disorder caused by mutations in the oculocerebrorenal gene (OCRL), encoding OCRL, a phosphatidylinositol 5-phosphatase with a RhoGAP domain. "
10/01/2003 - "Moreover, loss of OCRL1 RhoGAP and the resulting alteration in Rho pathways may contribute to mental retardation in Lowe syndrome, as illustrated in other forms of X-linked mental retardation."
07/08/2009 - "OCRL, whose mutations are responsible for Lowe syndrome and Dent disease, and INPP5B are two similar proteins comprising a central inositol 5-phosphatase domain followed by an ASH and a RhoGAP-like domain. "
05/01/2007 - "Dd5P4 is the Dictyostelium homolog of human OCRL (oculocerebrorenal syndrome of Lowe); both have a RhoGAP domain and a 5-phosphatase domain that acts on phosphatidylinositol 4,5-bisphosphate/phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3). "
|3.||Neoplasm Metastasis (Metastasis)
01/01/2013 - "PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis."
01/01/2010 - "P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis."
09/01/2006 - "These data suggest that the inhibitory action of p190 RhoGAP toward RhoA offers a novel approach to the treatment of invasion and metastasis of cancer cells."
07/15/2005 - "The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells."
09/01/2006 - "To investigate the biological function of p190 RhoGAP toward RhoA in cancer cell invasion and metastasis, we generated a chimera made of the RhoGAP domain of p190 and the C-terminus of RhoA (p190-RhoA chimera), and transfected it into human pancreatic cancer cells, AsPC-1. "
|4.||Nephrogenic Diabetes Insipidus
01/01/2002 - "Study of two families containing individuals with nephrogenic diabetes insipidus (NDI) indicated different types of 21.3 kb and 26.3 kb deletions involving the AVPR2 and ARHGAP4 (RhoGAP C1) genes. "
01/01/1999 - "Compound deletion of the rhoGAP C1 and V2 vasopressin receptor genes in a patient with nephrogenic diabetes insipidus."
12/01/2004 - "Expression of higher levels of tGAP1 by infection of somatic cells with recombinant adenoviruses demonstrated that tGAP1 efficiently induces apoptosis, which to our knowledge is the first such demonstration for a RhoGAP protein. "
08/01/2011 - "The objective of this study was to detect the associations between polymorphisms rs346473 and rs346482 in Rho GTPase-activating protein 24 (ARHGAP24) gene and disease progression of HBV infection in Han Chinese population. "
|1.||rho GTPase-activating protein
|2.||Proteins (Proteins, Gene)
|3.||rho GTP-Binding Proteins (rho GTP-Binding Protein)
|4.||GTP Phosphohydrolases (GTPases)
|6.||NF-kappa B (NF-kB)
|7.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|8.||Triose-Phosphate Isomerase (Triosephosphate Isomerase)
|9.||Glutathione Transferase (Glutathione S-Transferase)