|1.||Lombardo, L: 1 article (09/2008)|
|2.||Cardile, V: 1 article (09/2008)|
|3.||Russo, A: 1 article (09/2008)|
|4.||Piovano, M: 1 article (09/2008)|
|5.||Garbarino, J: 1 article (09/2008)|
|6.||Russo, Alessandra: 1 article (11/2006)|
|7.||Garbarino, Juan: 1 article (11/2006)|
|8.||Piovano, Marisa: 1 article (11/2006)|
|9.||Vanella, Luca: 1 article (11/2006)|
|10.||Lombardo, Laura: 1 article (11/2006)|
|1.||Prostatic Neoplasms (Prostate Cancer)
11/01/2006 - "Our data show an induction of apoptotic death of advanced prostate cancer cells by sphaerophorin, pannarin and epiphorellic acid-1. "
11/01/2006 - "In the course of our continuing search for new natural anticancer compounds for treatment and/or prevention of prostate cancer, our laboratory has focused its search on poorly investigated lichen metabolites, sphaerophorin, pannarin and epiphorellic acid-1. "
11/01/2006 - "Alternatively, we found a low, but significant (P<0.01) lactic dehydrogenase release at higher concentrations (50 micromol/l), suggesting that in these experimental conditions sphaerophorin, pannarin and epiphorellic acid-1 induce necrosis in DU-145 cells, through the increase in reactive oxygen species generation. "
|3.||Melanoma (Melanoma, Malignant)
09/26/2008 - "The data obtained in cell culture show that these lichen metabolites inhibit the growth of melanoma cells, inducing an apoptotic cell death, demonstrated by the fragmentation of genomic DNA (COMET and TUNEL Assays) and by a significant increase of caspase-3 activity, and correlated, at least in part, to the increase of ROS generation, These results confirm the promising biological properties of sphaerophorin and pannarin and encourage further investigations on their molecular mechanisms."
01/01/1997 - "Three secondary metabolites isolated from Chilean lichens, (+) usnic acid, pannarine and 1'-chloropannarine, were tested against promastigotes forms of three strains of Leishmania ssp. Pannarine and 1'-chloropannarine exhibited in vitro activity at 50 micrograms/ml and (+) usnic acid at 25 micrograms/ml. BALB/c mice infected with Leishmania amazonensis were treated 4 weeks post-infection with (+) usnic acid by subcutaneous or oral routes for 15 days at 25 mg/kg or by five intralesional injections at interval of 4 days at 25 mg/kg of body weight. "
11/01/1993 - "The effect of free radical scavengers, and the lack of effect of D2O in the medium, suggest that the hemolysis induced by pannarin and 1'chloropannarin is not mediated by (1)O2. "
11/01/1993 - "Irradiation of pannarin 1'-chloropannarin and antranorin with 366 nm light leads to significant hemolysis in a red cell suspension. "
11/01/1993 - "Hemolysis induced by pannarin and 1'chloropannarin increases in the presence of oxygen, whereas hemolysis induced by atranorin is higher in nitrogen-purged solutions. "
|3.||Caspase 3 (Caspase-3)
|4.||Reactive Oxygen Species (Oxygen Radicals)
|5.||Free Radical Scavengers
|9.||DNA (Deoxyribonucleic Acid)