MCI 225

a psychoactive cpd; enhances both noradrenergic and serotonergic function by inhibiting noradrenaline uptake and accelerating 5-hydroxytryptamine turnover, respectively

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Networked: 4 relevant articles (2 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Cognitive Dysfunction 02/01/1997 - "These data clearly show that MCI-225 enhances attention to a moving object and suggest that MCI-225 could be useful in the treatment of attentional deficits and related cognitive dysfunctions in psychiatric disorders."
2.	Mental Disorders (Mental Disorder) 02/01/1997 - "These data clearly show that MCI-225 enhances attention to a moving object and suggest that MCI-225 could be useful in the treatment of attentional deficits and related cognitive dysfunctions in psychiatric disorders."
3.	Alzheimer Disease (Alzheimer's Disease) 08/01/1995 - "These results suggest that MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypometabolism."
4.	Amnesia (Dissociative Amnesia) 06/01/1994 - "In a passive avoidance (PA) task, administration of MCI-225 prior to training (1-30 mg/kg, PO) lessened the carbon dioxide (CO2)-induced amnesia in a dose-dependent manner. " 06/01/1994 - "Effects of MCI-225, [4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-d]pyrimidine monohydrate hydrochloride] on experimental amnesia were studied in rats and compared with those of THA [9-amino-1,2,3,4-tetrahydroacridine]. " 08/01/1995 - "The effects of MCI-225 on amnesia, the cerebral glucose metabolism, and choline acetyltransferase (ChAT) activity in basal forebrain (BF)-lesioned rats were studied in comparison with those of tacrine. "
5.	Tremor (Tremors) 12/01/1997 - "MCI-225 and trazodone did not inhibit oxotremorine-induced tremor, lacrimation or salivation in mice in contrast with imipramine. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Trazodone (Trittico)
3.	Tacrine (Cognex)
4.	Oxotremorine
5.	Imipramine (Janimine)
6.	Choline O-Acetyltransferase (Choline Acetyltransferase)
7.	Carbon Dioxide
8.	pyrimidine