microtubule-associated protein 1B (MAP5)

an abundant developmentally regulated neuronal protein that is a stoichiometric complex of a heavy chain and 2 light chains, encoded as a polyprotein; essential for neuronal differentiation; MW 340 kDa; amino acid sequence has been determined

Also Known As:

Networked: 102 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Propst, Friedrich: 4 articles (01/2015 - 01/2005)
2.	Donner, Ludvik R: 3 articles (05/2012 - 05/2005)
3.	Gadoth, Avi: 2 articles (04/2022 - 02/2017)
4.	Feng, Wen-Cai: 2 articles (03/2021 - 11/2020)
5.	Fu, Jun-Yi: 2 articles (03/2021 - 11/2020)
6.	Gao, Mei-Mei: 2 articles (03/2021 - 11/2020)
7.	Hu, Fei: 2 articles (03/2021 - 11/2020)
8.	Jiang, Wei: 2 articles (03/2021 - 11/2020)
9.	Long, Jing-Yi: 2 articles (03/2021 - 11/2020)
10.	Long, Yue-Sheng: 2 articles (03/2021 - 11/2020)

Related Diseases

1.	Body Weight (Weight, Body) 03/01/2021 - "Corrigendum to "FMRP-absence-induced up-regulation of hypothalamic MAP1B expression decreases AgRP level linking with reduces in food intake and body weight" [Neurochem. " 11/01/2020 - "Taken together, these data suggest that FMRP-deficiency-induced increase of hypothalamic MAP1B and decrease of AgRP might be associated with reduces in food intake and body weight." 11/01/2020 - "We further showed an age-dependent reduces in food intake and body weight of the KO mice, along with the decreases of MAP1B and AgRP at the same time points. " 11/01/2020 - "FMRP-absence-induced up-regulation of hypothalamic MAP1B expression decreases AgRP level linking with reduces in food intake and body weight." 01/01/2017 - "Motor scoring index was significantly improved after the intervention in groups 2 and 3. The ratio of phospho-protein kinase C (PKC) to PKC measured in the infarcted area tended to be higher in groups 3 and 4. Protein expression of mGluR2 and mRNA expression of mGluR1 measured in the contralateral cortex were lower in groups 3 and 4. The ratio of phospho-Akt to Akt and mRNA expression of vascular endothelial growth factor measured in the ischemic border zone were higher in group 2. The mRNA expression of MAP1b measured in the infarcted area was significantly higher in group 2. The findings suggest that LSCS and gait training with an adequate amount of body weight support may promote brain plasticity and facilitate the functional recovery."
2.	Pathologic Processes 10/01/2010 - "These results suggest that RPL15 and MAP1B may be involved in the regulation of pathological processes in bovine FCOs and may help to establish a bovine gene data-base for the discrimination of FCOs from normal ovaries." 01/01/2004 - "We also discuss the role of MAP1B in pathological processes."
3.	Neoplasms (Cancer) 01/01/2023 - "Using bioinformatics analysis from The Cancer Genome Atlas (TCGA) database and proteomic analysis from our BC cohort, we constructed and validated an effective prognostic prediction model for BC patients based on four differentially expressed ERGs (MAP1B, FBN1, COL6A1, and MFAP5). " 11/01/2020 - "Other cancer-related mutations identified in more than one case were MAF (2/23), NEB (6/23), NCOR1 (2/23), TTK (2/23), GRIN3A (4/23), TRIO (2/23), MAP1B (2/23), TJP2 (2/23) and FAM20A (2/23). " 01/01/2018 - "Finally, we found two cancer-associated mutations of human MAP1B located near ALG-2 binding sites. " 08/01/2015 - "CCDC37 and MAP1B expression was dramatically repressed in tumors and CFLT from COPD than non-COPD cases, p less than 0.02. " 08/01/2015 - "HM450K probes across CCDC37 and MAP1B promoters showed higher methylation in tumors than CFLT with the highest methylation seen in tumors from COPD cases (p < 0.05). "
4.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 06/01/2016 - "The aim of this study was to examine the association between rs2199161 and rs478597 polymorphisms at MAP1B and NOS1 genes with verbal working memory in children and adolescents with ADHD. " 04/01/2016 - "The aim of the present study was to examine possible associations between polymorphisms in SNAP25, MAP1B and NOS1 genes and ADHD symptoms in Brazilian samples of children/adolescents and adults with ADHD. " 06/01/2016 - "Our findings suggest possible roles of NOS1 and MAP1B genes in WM performance in ADHD patients, replicating previous results with NOS1 gene in this cognitive domain in ADHD children. " 06/01/2016 - "MAP1B and NOS1 genes are associated with working memory in youths with attention-deficit/hyperactivity disorder."
5.	Periventricular Nodular Heterotopia 04/01/2021 - "Recently, studies on whole-exome sequencing (WES) of large cohorts of people with periventricular heterotopia (PVH) have reported an association with loss-of-function variants in the MAP1B gene. " 01/01/2023 - "Teaching NeuroImage: New Pattern of Periventricular Nodular Heterotopia in Twins With a Pathogenic Variant in the MAP1B Gene." 01/01/2018 - "De novo and inherited private variants in MAP1B in periventricular nodular heterotopia." 01/01/2019 - "MAP1B mutations have recently been associated with a phenotype including periventricular nodular heterotopia (PVNH), intellectual disability (ID), seizures, and dysmorphic features. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Messenger RNA (mRNA)
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Protein Kinase C
5.	metabotropic glutamate receptor 2
6.	metabotropic glutamate receptor type 1
7.	microtubule-associated protein 1B (MAP5)
8.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
9.	Glial Fibrillary Acidic Protein
10.	Microcystins

Related Therapies and Procedures

1.	Precision Medicine
2.	Drug Therapy (Chemotherapy)