SR 140333

SR-140603 is the (R)-antipode of SR-140333; a neurokinin-1 receptor antagonist

Also Known As:

1-(2-(3-(3,4-dichlorophenyl)-1-(3-isopropoxyphenylacetyl)piperidin-3-yl)ethyl)-4-phenyl-1-azabicyclo(2.2.2)octane chloride; SR 140,333; SR 140603; SR-140,333; SR-140333; SR-140603; SR140,333; SR140333; 1-Azoniabicyclo(2.2.2)octane, 1-(2-(3-(3,4-dichlorophenyl)-1-((3-(1-methylethoxy)phenyl)acetyl)-3-piperidinyl)ethyl)-4-phenyl-, chloride, (S)-

Networked: 51 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - SR 140333: 51
- Bridged-Ring Heterocyclic Compounds
  - Quinuclidines: 20
    - SR 140333: 51

Experts

1.	Cheng, Xurui: 2 articles (11/2021 - 01/2020)
2.	Fu, Caiyun: 2 articles (11/2021 - 01/2020)
3.	Meng, Yueming: 2 articles (11/2021 - 01/2020)
4.	Shao, Gang: 2 articles (11/2021 - 01/2020)
5.	Wang, Lingfei: 2 articles (11/2021 - 01/2020)
6.	Wang, Xi: 2 articles (11/2021 - 01/2020)
7.	Costa, Soraia K P: 2 articles (01/2015 - 10/2011)
8.	Advenier, C: 2 articles (09/2004 - 11/2000)
9.	Bueno, Lionel: 2 articles (04/2003 - 04/2002)
10.	Fioramonti, Jean: 2 articles (04/2003 - 04/2002)

Related Diseases

1.	Colitis 02/01/1999 - "In conclusion, treatment with SP antagonist SR140333 reduces the severity of colitis and has beneficial effects on the concomitant alterations of contractility. " 02/01/1999 - "At day 14, the control group showed no signs of inflammation whereas the TNB-treated rats without SR140333 treatment exhibited a well-established colitis. " 02/01/1999 - "In this study we evaluated the ability of a SP-antagonist (SR140333) to modify the course of experimental colitis induced in the rat by trinitrobenzene sulfonic acid (TNB). " 01/28/2009 - "In conclusion, treatment with SR140333 protects from DNBS-induced colitis in rats. " 02/01/1999 - "SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis."
2.	Inflammation (Inflammations) 09/28/1999 - "The exacerbated inflammation in knockout mice was prevented by recombinant NEP and SR140333. " 02/01/1999 - "At day 14, the control group showed no signs of inflammation whereas the TNB-treated rats without SR140333 treatment exhibited a well-established colitis. " 01/01/1998 - "In TNBS treated rats, daily administration of SR 140333 (0.3 mg/kg/day) and SR 48968 (5 mg/kg/day) reduced colonic inflammation. " 02/01/1999 - "Therefore, in a guinea pig model of allergic asthma, we investigated the involvement of the NK1 receptor in allergen-induced early (EAR) and late (LAR) asthmatic reactions, airway hyperreactivity (AHR) after these reactions and airway inflammation, using the selective nonpeptide NK1 receptor antagonist SR140333. " 01/01/2000 - "We did not observe a significant inhibitory effect of SR140333 on the nerve growth factor content in non-treated skin, or the nerve growth factor increase caused by carrageenan or allergic inflammation. "
3.	Respiratory Hypersensitivity 06/07/2007 - "CGRP(8-37) or combination of SR 140333 and SR 48968 diminished neutrophil accumulation, MPO levels and IL-1beta production, airway hyperresponsiveness was inhibited only by SR 48968. " 08/01/1997 - "[Effect of SR-140333, a tachykinin NK-1 antagonist, on antigen-induced airway hyperresponsiveness in sensitized rats]." 05/01/1996 - "We conducted a study designed to describe an original model of airway hyperresponsiveness induced by citric acid administered as aerosol to guinea pigs, and to investigate the effects of the nonpeptide neurokinin1 (NK1) and neurokinin2 (NK2)-receptor antagonists, SR 140333 and SR 48968, respectively, on the development of this airway hyperresponsiveness. " 05/01/1996 - "SR 48968 1 mg/kg intraperitoneally, given once at 30 min before the citric acid exposure, inhibited airway hyperresponsiveness, whereas SR 140333 1 mg/kg or codeine 30 mg/kg given under similar conditions did not. " 01/01/1995 - "The involvement of tachykinins in antigen-induced airway hyperresponsiveness (AHR) was characterized pharmacologically in guinea-pigs sensitized to ovalbumin with antagonists of tachykinin NK1 and NK2 receptors, namely SR 140333 and SR 48968, respectively. "
4.	Astrocytoma (Pilocytic Astrocytoma) 04/01/1994 - "The effects of a novel nonpeptide NK1 tachykinin receptor antagonist, SR 140333, on the functional consequences of NK1 receptor activation in a human astrocytoma cell line, U373MG, were investigated. " 12/16/1996 - "In the first part of this study, we showed that SR 140333, an NK1 tachykinin receptor antagonist, was able to inhibit strongly the SP-induced production of interleukin (IL)-6 and IL-8 in the astrocytoma cell line. "
5.	Lung Injury 09/01/2007 - "To further substantiate the role of SP in sepsis and to study its mechanism, we have evaluated the effect of SR140333, a SP receptor antagonist, on lung injury in sepsis, which was induced in male Swiss mice by cecal ligation and puncture (CLP). "

Related Drugs and Biologics

1.	Aerosols
2.	Tachykinins
3.	SR 48968 (saredutant)
4.	Neurokinin-1 Receptors (Neurokinin 1 Receptor)
5.	Antigens
6.	Citric Acid (Citrate)
7.	Tachykinin Receptors (Tachykinin Receptor)
8.	Sulfonic Acids
9.	Substance P
10.	Interleukins

Related Therapies and Procedures

1.	Punctures
2.	Ligation
3.	Aftercare (After-Treatment)