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nexopamil
RN refers to (2S)-isomer; structure given in first source
Also Known As:
5-(N-methyl-N-(n-hexyl))amino-2-(3,4,5-trimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride; LU 49938; LU-49938; LU49938
Networked:
3
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Ethylamines: 5
Phenethylamines: 28
Verapamil: 6163
nexopamil: 3
Related Diseases
1.
Ventricular Tachycardia
06/01/1996 - "
We examined the efficacy of nexopamil, which possesses the unique combination of calcium channel and 5-HT2 receptor blockade, in preventing ventricular tachycardia (VT) and fibrillation (VF) and reducing T-wave alternans magnitude during coronary artery occlusion and abrupt reperfusion in dogs.
"
2.
Coronary Occlusion
06/01/1994 - "
Nexopamil decreased left ventricular peak pressure (LVPP) and pressure rate index (PRI) immediately before coronary occlusion by 11 and 18%, respectively.
"
06/01/1994 - "
Coronary occlusion resulted in increased platelet reactivity in coronary venous blood (collagen-induced aggregation) that was prevented by nexopamil.
"
3.
Myocardial Ischemia (Ischemic Heart Diseases)
06/01/1996 - "
Potent antifibrillatory effect of combined blockade of calcium channels and 5-HT2 receptors with nexopamil during myocardial ischemia and reperfusion in dogs: comparison to diltiazem.
"
4.
Thrombosis (Thrombus)
11/01/1993 - "
We investigated the effects of nexopamil, a combined Ca2+/5-HT2 antagonist on thrombus formation in vivo and on platelet aggregation in vitro.
"
11/01/1993 - "
Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage.
"
5.
Ischemia
06/01/1994 - "
Besides calcium channel blocking activity, inhibition of ischemia-induced neutrophil activation and enhanced endogenous PGI2 formation may be factors contributing to the beneficial effects of nexopamil.
"
06/01/1994 - "
We investigated the ability of a newly developed calcium and serotonin (5-HT2) antagonist, nexopamil, to protect the heart from ischemia- and reperfusion-induced myocardial injury.
"
Related Drugs and Biologics
1.
Calcium Channels (Calcium Channel)
2.
nexopamil
3.
Serotonin 5-HT2 Receptor Antagonists
4.
Serotonin (5 Hydroxytryptamine)
5.
Methoxamine (Methoxamine Hydrochloride)
6.
Coloring Agents (Dyes)
7.
Diltiazem (Cardizem)
8.
Collagen
9.
Calcium