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N(6)- (3- iodobenzyl)- 5'- N- methylcarboxamidoadenosine

structure given in first source; a selective A(3) adenosine receptor agonist
Also Known As:
3-IB-MECA; IB-MECA; N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide; N(6)-IBAMU
Networked: 64 relevant articles (13 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Jacobson, Kenneth A: 6 articles (04/2015 - 01/2006)
2. Madi, Lea: 6 articles (01/2013 - 06/2002)
3. Fishman, Pnina: 6 articles (10/2007 - 06/2002)
4. Bar-Yehuda, Sara: 6 articles (10/2007 - 06/2002)
5. Salvemini, Daniela: 4 articles (04/2015 - 05/2012)
6. Ochaion, Avivit: 4 articles (10/2007 - 05/2003)
7. Tosh, Dilip K: 3 articles (04/2015 - 01/2009)
8. Doyle, Timothy: 3 articles (04/2015 - 12/2014)
9. Janes, Kali: 3 articles (02/2015 - 05/2012)
10. Panjehpour, Mojtaba: 3 articles (11/2014 - 08/2004)

Related Diseases

1. Ischemia
2. Infarction
03/16/2001 - "We investigated whether activation of A(1) or A(3) adenosine receptors (ARs) induces late preconditioning (PC) against infarction in conscious rabbits using the selective AR agonists 2-chloro-N(6)-cyclopentyladenosine (CCPA) and N(6)-3-iodobenzyladenosine-5'-N-methylcarboxamide (IB-MECA). "
08/01/2001 - "Recent studies have demonstrated that the adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) and the adenosine A3 receptor agonist N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) produce a delayed phase of protection against infarction similar to the late phase of ischemic preconditioning (PC). "
06/01/1997 - "To examine the cardioprotective role of A3 adenosine receptors during myocardial ischemia/reperfusion injury, we tested the effect of N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), a potent and selective A3 adenosine receptor agonist, in models of myocardial stunning and infarction in chronically instrumented conscious rabbits. "
07/01/2006 - "IB-MECA enhanced phosphorylation of GSK-3beta (Ser9) upon reperfusion, and the GSK-3 inhibitor 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763) (3 microM) mimicked the protective effect of IB-MECA by attenuating both infarction and the loss of DeltaPsim. "
06/01/1997 - "These results demonstrate that in conscious rabbits the A3 adenosine receptor agonist IB-MECA confers a powerful protection against both reversible (stunning) and irreversible (infarction) injury during acute myocardial ischemia and reperfusion by a protein kinase C-mediated pathway, suggesting that selective activation of A3 receptors is an effective means of protecting the ischemic myocardium without hemodynamic changes."
3. Myocardial Stunning (Stunned Myocardium)
4. Lung Injury
5. Necrosis

Related Drugs and Biologics

1. Adenosine A3 Receptor
2. Adenosine A1 Receptor
3. Purinergic P1 Receptors (Adenosine Receptor)
4. MRS 1191
5. Staphylococcal Protein A (A, Protein)
6. Phosphotransferases (Kinase)
7. 1,4-dihydropyridine (dihydropyridine)
8. Adenosine
9. 2- chloro- N(6)- (3- iodobenzyl)- 5'- N- methylcarboxamidoadenosine (Cl-IB-MECA)
10. purine

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)