cis-isoprenyltransferase

cis-isoprene units of dolichyl monophosphate are added to trans,trans-farnesyl pyrophosphate using isopentenyl pyrophosphate as donor; from embryonic rat brain

Also Known As:

long-chain cis-isoprenyltransferase

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Alkyl and Aryl Transferases: 180
      - cis-isoprenyltransferase: 1

Related Diseases

Glioma (Gliomas)

09/01/1995 - "Direct in vitro enzyme studies with membrane fractions from primary cultures of embryonic rat brain (IC50 = 37 nM), pig brain (IC50 = 21 nM), and C6 glioma cells (IC50 = 35 nM) demonstrated that SQ potently inhibited squalene synthase activity but had no effect on the long-chain cis-isoprenyltransferase catalyzing the conversion of F-P-P to polyprenyl pyrophosphate (Poly-P-P), the precursor of dolichyl phosphate (Dol-P). "

Related Drugs and Biologics

1.	Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)
2.	Enzymes
3.	dolichol monophosphate (dolichyl phosphate)
4.	polyprenylpyrophosphate