polydeoxyadenylic acid-polythymidylic acid
double-stranded homopolymer; RN refers to sodium salt
Also Known As:
poly (dA).poly (dT)
Networked: 5
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Bio-Agent Context: Research Results
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Related Diseases
1. | Dehydration (Water Stress)
07/26/1994
- " On the basis of apparent molar volume, phi V, and apparent molar adiabatic compressibility, phi Ks, values for the initial drug-free and final drug-bound states of the two all-AT duplexes, we propose that the larger dehydration of the poly(dA).poly(dT) duplex reflects, in part, the formation of a less hydrated poly(dA).poly(dT)-netropsin complex compared with the corresponding poly(dAdT).poly(dAdT)-netropsin complex. " 07/26/1994
- " When netropsin binds to the poly(dT).poly(dA).poly(dT) triplex, the changes in both volume and compressibility suggest that the binding event induces more dehydration of the triplex than of the duplex state. " 06/12/1989
- " The following conclusions have been made: (1) the hydration of the double helix of poly(dA).poly(dT) is remarkably larger than that of other polynucleotides; (2) the hydration of the AT pair in the B-form DNA is larger than that of the GC pair; (3) the substitution of Cs+ for Mg2+ ions as counter ions results in a decrease of hydration of the system polynucleotide plus Mg2+, and (4) the magnitude of this dehydration depends on the nucleotide sequence; the following rule is true: the lesser is a polynucleotide hydration, the larger dehydration upon changing Cs+ for Mg2+ ions in the ionic atmosphere of polynucleotide."
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2. | Poisoning
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3. | Neoplasms (Cancer)
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4. | Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature
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